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Tbio
MIER1
Mesoderm induction early response protein 1

Protein Summary
Description
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355356
  • ENSP00000347514
  • ENSG00000198160
  • ENST00000355977
  • ENSP00000348253
  • ENST00000357692
  • ENSP00000350321
  • ENST00000371012
  • ENSP00000360051
  • ENST00000371014
  • ENSP00000360053
  • ENST00000371016
  • ENSP00000360055
  • ENST00000371018
  • ENSP00000360057
  • ENST00000401041
  • ENSP00000383820
  • ENST00000401042
  • ENSP00000383821

Symbol
  • KIAA1610
  • ER1
  • MI-ER1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
histone modification site profile
0.86
virus perturbation
0.85
transcription factor perturbation
0.8
transcription factor
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.04   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.04   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999836
p_ni:  1.64e-7
Score:  0.47
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999999672
p_ni:  3.28e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
C16orf87
Tdark
Novelty:  5.71664261
p_int:  0.99999963
p_ni:  3.7e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999998636
p_ni:  0.000001363
Score:  0.705
Data Source:  BioPlex,STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
p_int:  0.999998127
p_ni:  0.000001873
Score:  0.869
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999989824
p_ni:  0.000010176
Score:  0.329
Data Source:  BioPlex,STRINGDB
CDYL
Tchem
Family:  Epigenetic
Novelty:  0.03367841
p_int:  0.999972165
p_ni:  0.000027835
Score:  0.921
Data Source:  BioPlex,STRINGDB
DR1
Tbio
Novelty:  0.00138571
p_int:  0.999595359
p_ni:  0.000404628
p_wrong:  1.3e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
FAM170A
Tdark
Novelty:  0.05778712
p_int:  0.990535577
p_ni:  0.009464423
Score:  0.209
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.878367339
p_ni:  0.108649952
p_wrong:  0.01298271
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
92.9
lymphocyte percentage of leukocytes
2
2
2
81
serum urea measurement
1
1
1
77.4
monocyte count
1
1
1
69.4
leukocyte count
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
92.9
lymphocyte percentage of leukocytes
2
81
serum urea measurement
1
77.4
monocyte count
1
69.4
leukocyte count
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MIER1 transcriptional regulator
VGNC:1321
469347
Macaque
MIER1 transcriptional regulator
704161
Mouse
MGI:1918398
71148
Rat
RGD:1562337
313418
Dog
MIER1 transcriptional regulator
VGNC:43229
479536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MIER1 transcriptional regulator
Macaque
MIER1 transcriptional regulator
Mouse
Rat
Dog
MIER1 transcriptional regulator
Publication Statistics
PubMed Score 339.04
PubMed score by year
PubTator Score 66.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title