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Tbio
MIER1
Mesoderm induction early response protein 1

Protein Summary
Description
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355356
  • ENSP00000347514
  • ENSG00000198160
  • ENST00000355977
  • ENSP00000348253
  • ENST00000357692
  • ENSP00000350321
  • ENST00000371012
  • ENSP00000360051
  • ENST00000371014
  • ENSP00000360053
  • ENST00000371016
  • ENSP00000360055
  • ENST00000371018
  • ENSP00000360057
  • ENST00000401041
  • ENSP00000383820
  • ENST00000401042
  • ENSP00000383821

Symbol
  • KIAA1610
  • ER1
  • MI-ER1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
histone modification site profile
0.86
virus perturbation
0.85
transcription factor perturbation
0.8
transcription factor
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.44   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.44   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0