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Tbio
MIDN
Midnolin

Protein Summary
Description
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300952
  • ENSP00000300952
  • ENSG00000167470
  • ENST00000591446
  • ENSP00000467679
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
transcription factor
0.82
cell type or tissue
0.7
microRNA
0.68
gene perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
TNNC1
Tclin
Novelty:  0.03535727
p_int:  0.999999945
p_ni:  5.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
EGR1
Tbio
Family:  TF
Novelty:  0.00039994
p_int:  0.999999674
p_ni:  3e-8
p_wrong:  2.96e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
NR4A1
Tchem
Family:  NR
Novelty:  0.00150135
p_int:  0.999993743
p_ni:  0.000006254
p_wrong:  3e-9
Score:  0.38
Data Source:  BioPlex,STRINGDB
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.999743394
p_ni:  0.000021413
p_wrong:  0.000235193
Score:  0.193
Data Source:  BioPlex,STRINGDB
DDX42
Tchem
Family:  Enzyme
Novelty:  0.06068814
Score:  0.905
Data Source:  STRINGDB
TP53BP2
Tbio
Novelty:  0.01058379
Score:  0.804
Data Source:  STRINGDB
UBL7
Tdark
Novelty:  0.20935024
Score:  0.694
Data Source:  STRINGDB
C19orf24
Tdark
Novelty:  0.72451174
Score:  0.669
Data Source:  STRINGDB
SBNO2
Tbio
Novelty:  0.07377297
Score:  0.612
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.538
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
8
98.1
reticulocyte measurement
3
3
3
94.2
reticulocyte count
7
2
7
91.4
lymphocyte count
1
5
5
91.1
lymphocyte percentage of leukocytes
1
2
2
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
98.1
reticulocyte measurement
3
94.2
reticulocyte count
7
91.4
lymphocyte count
5
91.1
lymphocyte percentage of leukocytes
2
85.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
midnolin [Source:HGNC Symbol;Acc:HGNC:16298]
Mouse
MGI:1890222
59090
Rat
RGD:1309629
314623
Dog
midnolin
VGNC:43225
485087
Cow
midnolin
VGNC:31466
523615
Species
Name
OMA
EggNOG
Inparanoid
Macaque
midnolin [Source:HGNC Symbol;Acc:HGNC:16298]
Mouse
Rat
Dog
midnolin
Cow
midnolin
Publication Statistics
PubMed Score 14.89
PubMed score by year
PubTator Score 4.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title