Protein Summary
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
- ENST00000300952
- ENSP00000300952
- ENSG00000167470
- ENST00000591446
- ENSP00000467679
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.97 | ||
transcription factor | 0.82 | ||
cell type or tissue | 0.7 | ||
microRNA | 0.68 | ||
gene perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.89 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 116 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.89 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 116 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (25)
EGR1
Family: TF
Novelty: 0.00039994
p_int: 0.999999674
p_ni: 3e-8
p_wrong: 2.96e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
NR4A1
Family: NR
Novelty: 0.00150135
p_int: 0.999993743
p_ni: 0.000006254
p_wrong: 3e-9
Score: 0.38
Data Source: BioPlex,STRINGDB
ERCC6L
Novelty: 0.01959203
p_int: 0.999743394
p_ni: 0.000021413
p_wrong: 0.000235193
Score: 0.193
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 5 | 8 | 98.1 | |||||
reticulocyte measurement | 3 | 3 | 3 | 94.2 | |||||
reticulocyte count | 7 | 2 | 7 | 91.4 | |||||
lymphocyte count | 1 | 5 | 5 | 91.1 | |||||
lymphocyte percentage of leukocytes | 1 | 2 | 2 | 85.5 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 8 | 98.1 | |||||
reticulocyte measurement | 3 | 94.2 | |||||
reticulocyte count | 7 | 91.4 | |||||
lymphocyte count | 5 | 91.1 | |||||
lymphocyte percentage of leukocytes | 2 | 85.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | midnolin [Source:HGNC Symbol;Acc:HGNC:16298] | |||||||
Mouse | MGI:1890222 | 59090 | ||||||
Rat | RGD:1309629 | 314623 | ||||||
Dog | midnolin | VGNC:43225 | 485087 | |||||
Cow | midnolin | VGNC:31466 | 523615 | |||||
Publication Statistics
PubMed Score 14.89
PubMed score by year
PubTator Score 4.17
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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