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Tbio
MID2
Probable E3 ubiquitin-protein ligase MID2

Protein Summary
Description
May play a role in microtubule stabilization. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262843
  • ENSP00000262843
  • ENSG00000080561
  • ENST00000443968
  • ENSP00000413976

Symbol
  • FXY2
  • RNF60
  • TRIM1
  • FXY2
  • RNF60
  • TRIM1
  • MRX101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.96
kinase perturbation
0.71
molecular function
0.7
biological process
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.3   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.3   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.999999663
p_ni:  3.34e-7
p_wrong:  3e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999999528
p_ni:  4.69e-7
p_wrong:  3e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
EPN3
Tbio
Novelty:  0.12685855
p_int:  0.99979066
p_ni:  0.000027522
p_wrong:  0.000181818
Score:  0.207
Data Source:  BioPlex,STRINGDB
SYT17
Tbio
Novelty:  0.03921503
p_int:  0.789103121
p_ni:  0.000146341
p_wrong:  0.210750538
Score:  0.557
Data Source:  BioPlex,STRINGDB
SURF6
Tbio
Novelty:  0.0507355
Score:  0.756
Data Source:  STRINGDB
COL4A6
Tbio
Novelty:  0.02524039
Score:  0.721
Data Source:  STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.684
Data Source:  STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
Score:  0.654
Data Source:  STRINGDB
PRSS50
Tbio
Family:  Enzyme
Novelty:  0.01511883
Score:  0.654
Data Source:  STRINGDB
PRPS1L1
Tdark
Family:  Kinase
Novelty:  0.02527534
Score:  0.65
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
midline 2
VGNC:1510
107971018
Mouse
MGI:1344333
23947
Rat
RGD:1565674
363502
Dog
midline 2
VGNC:43224
481012
Horse
midline 2
VGNC:20177
100054631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
midline 2
Mouse
Rat
Dog
midline 2
Horse
midline 2
Publication Statistics
PubMed Score 77.30
PubMed score by year
PubTator Score 24.49
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title