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Tbio
MID1
E3 ubiquitin-protein ligase Midline-1

Protein Summary
Description
Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317552
  • ENSP00000312678
  • ENSG00000101871
  • ENST00000380779
  • ENSP00000370156
  • ENST00000380780
  • ENSP00000370157
  • ENST00000380782
  • ENSP00000370159
  • ENST00000380785
  • ENSP00000370162
  • ENST00000380787
  • ENSP00000370164
  • ENST00000453318
  • ENSP00000414521

Symbol
  • FXY
  • RNF59
  • TRIM18
  • XPRF
  • OS
  • FXY
  • OSX
  • OGS1
  • XPRF
  • BBBG1
  • GBBB1
  • MIDIN
  • RNF59
  • ZNFXY
  • TRIM18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
ligand (protein) perturbation
0.96
transcription factor perturbation
0.96
microRNA
0.81
transcription factor
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.92   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.92   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0