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Tbio
MICU3
Calcium uptake protein 3, mitochondrial

Protein Summary
Description
May play a role in mitochondrial calcium uptake.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318063
  • ENSP00000321455
  • ENSG00000155970

Symbol
  • EFHA2
  • EFHA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
microRNA
0.78
trait
0.75
gene perturbation
0.59
tissue sample
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.58   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.58   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.999999932
p_ni:  1e-8
p_wrong:  5.9e-8
Score:  0.808
Data Source:  BioPlex,STRINGDB
MICU1
Tbio
Novelty:  0.00984731
p_int:  0.998753401
p_ni:  1.65e-7
p_wrong:  0.001246434
Score:  0.986
Data Source:  BioPlex,STRINGDB
MCUB
Tbio
Novelty:  0.0486243
Score:  0.984
Data Source:  STRINGDB
MCU
Tbio
Family:  IC
Novelty:  0.00114914
Score:  0.977
Data Source:  STRINGDB
SMDT1
Tbio
Novelty:  0.02448475
Score:  0.974
Data Source:  STRINGDB
FGF20
Tbio
Novelty:  0.0145462
Score:  0.921
Data Source:  STRINGDB
AFG3L2
Tbio
Family:  Enzyme
Novelty:  0.01770465
Score:  0.902
Data Source:  STRINGDB
PHB
Tbio
Novelty:  0.00178383
Score:  0.9
Data Source:  STRINGDB
MAIP1
Tbio
Novelty:  0.28004667
Score:  0.9
Data Source:  STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
3
1
0
1.1
69.4
educational attainment
1
2
2
44.4
self reported educational attainment
1
1
1
2.9
triacylglycerol 52:2 measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
0
1.1
69.4
educational attainment
2
44.4
self reported educational attainment
1
2.9
triacylglycerol 52:2 measurement
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake family member 3
VGNC:3008
464004
Macaque
mitochondrial calcium uptake family member 3
701957
Mouse
MGI:1925756
78506
Rat
RGD:1563411
364601
Dog
mitochondrial calcium uptake family member 3
VGNC:51813
606938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uptake family member 3
Macaque
mitochondrial calcium uptake family member 3
Mouse
Rat
Dog
mitochondrial calcium uptake family member 3
Publication Statistics
PubMed Score 10.58
PubMed score by year
PubTator Score 0.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title