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Tbio
MICALL1
MICAL-like protein 1

Protein Summary
Description
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215957
  • ENSP00000215957
  • ENSG00000100139

Symbol
  • KIAA1668
  • MIRAB13
  • MIRAB13
  • MICAL-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cellular component
0.69
molecular function
0.63
tissue sample
0.61
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999999989
p_ni:  1e-9
p_wrong:  1e-8
Score:  0.176
Data Source:  BioPlex,STRINGDB
RAB8B
Tbio
Family:  Enzyme
Novelty:  0.06230082
p_int:  0.999999966
p_ni:  3.3e-8
p_wrong:  2e-9
Score:  0.482
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.998520178
p_ni:  0.001158142
p_wrong:  0.00032168
Data Source:  BioPlex
PACSIN3
Tbio
Family:  Enzyme
Novelty:  0.11715903
p_int:  0.990137165
p_ni:  0.007129885
p_wrong:  0.00273295
Score:  0.322
Data Source:  BioPlex,STRINGDB
EHD1
Tbio
Novelty:  0.00817602
Score:  0.922
Data Source:  STRINGDB
RAB35
Tbio
Family:  Enzyme
Novelty:  0.01514601
Score:  0.901
Data Source:  STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.84
Data Source:  STRINGDB
EHD3
Tbio
Novelty:  0.02008691
Score:  0.839
Data Source:  STRINGDB
RAB13
Tbio
Family:  Enzyme
Novelty:  0.02465609
Score:  0.817
Data Source:  STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.814
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
2
2
72.4
heel bone mineral density
2
1
2
67.1
red blood cell distribution width
1
1
1
55.2
smoking status measurement
2
1
2
46.9
alkaline phosphatase measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
72.4
heel bone mineral density
2
67.1
red blood cell distribution width
1
55.2
smoking status measurement
2
46.9
alkaline phosphatase measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MICAL like 1
VGNC:6025
458822
Mouse
MGI:105870
27008
Rat
RGD:1305415
362958
Dog
MICAL like 1
VGNC:54528
481260
Horse
MICAL like 1
100069931
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MICAL like 1
Mouse
Rat
Dog
MICAL like 1
Horse
MICAL like 1
Publication Statistics
PubMed Score 11.58
PubMed score by year
PubTator Score 8.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title