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Tbio
MICAL1
[F-actin]-monooxygenase MICAL1

Protein Summary
Description
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358577
  • ENSP00000351385
  • ENSG00000135596
  • ENST00000358807
  • ENSP00000351664
  • ENST00000630715
  • ENSP00000486901

Symbol
  • MICAL
  • NICAL
  • MICAL
  • NICAL
  • MICAL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
transcription factor perturbation
0.8
histone modification site profile
0.78
protein domain
0.73
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.74   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.74   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
p_int:  0.999971009
p_ni:  0.00002899
Score:  0.317
Data Source:  BioPlex,STRINGDB
ZNF517
Tdark
Family:  TF
Novelty:  1.60617003
p_int:  0.999887061
p_ni:  0.000112937
p_wrong:  1e-9
Data Source:  BioPlex
CASS4
Tbio
Novelty:  0.01000437
p_int:  0.999366025
p_ni:  0.000633975
Score:  0.361
Data Source:  BioPlex,STRINGDB
USH1G
Tbio
Novelty:  0.02912203
p_int:  0.998568376
p_ni:  0.001431588
p_wrong:  3.6e-8
Score:  0.408
Data Source:  BioPlex,STRINGDB
TBCA
Tbio
Novelty:  0.07587729
p_int:  0.997747598
p_ni:  0.002252129
p_wrong:  2.73e-7
Data Source:  BioPlex
TAS2R7
Tchem
Family:  GPCR
Novelty:  0.10029148
p_int:  0.996173199
p_ni:  0.003798204
p_wrong:  0.000028597
Score:  0.224
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.995576485
p_ni:  0.004190995
p_wrong:  0.00023252
Data Source:  BioPlex
SERHL2
Tdark
Family:  Enzyme
Novelty:  0.25704218
p_int:  0.995500667
p_ni:  0.004496484
p_wrong:  0.000002849
Score:  0.203
Data Source:  BioPlex,STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
p_int:  0.994293887
p_ni:  0.005658908
p_wrong:  0.000047205
Score:  0.175
Data Source:  BioPlex,STRINGDB
HBG2
Tbio
Novelty:  0.01145628
p_int:  0.992077895
p_ni:  0.00791936
p_wrong:  0.000002745
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
80.6
mosaic loss of chromosome Y measurement
2
1
2
79.9
reticulocyte count
1
1
1
69.5
lymphocyte percentage of leukocytes
1
1
1
56.6
lymphocyte count
2
2
2
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
80.6
mosaic loss of chromosome Y measurement
2
79.9
reticulocyte count
1
69.5
lymphocyte percentage of leukocytes
1
56.6
lymphocyte count
2
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated monooxygenase, calponin and LIM domain containing 1
VGNC:8171
463145
Macaque
microtubule associated monooxygenase, calponin and LIM domain containing 1
698737
Mouse
MGI:2385847
171580
Rat
RGD:1309386
294520
Dog
microtubule associated monooxygenase, calponin and LIM domain containing 1
VGNC:49758
481958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated monooxygenase, calponin and LIM domain containing 1
Macaque
microtubule associated monooxygenase, calponin and LIM domain containing 1
Mouse
Rat
Dog
microtubule associated monooxygenase, calponin and LIM domain containing 1
Publication Statistics
PubMed Score 44.74
PubMed score by year
PubTator Score 37.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title