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Tbio
MICA
MHC class I polypeptide-related sequence A

Protein Summary
Description
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400325
  • ENSP00000383179
  • ENSG00000183214
  • ENST00000418465
  • ENSP00000402134
  • ENSG00000235233
  • ENST00000547609
  • ENSP00000446963

Symbol
  • PERB11.1
  • MIC-A
  • PERB11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
disease
0.85
protein domain
0.85
phenotype
0.78
biological process
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.59   (req: < 5)
Gene RIFs: 316   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.59   (req: >= 5)
Gene RIFs: 316   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
ADAP2
Tbio
Novelty:  0.11270592
p_int:  0.999944285
p_ni:  0.000055715
Score:  0.237
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.999909675
p_ni:  0.000090322
p_wrong:  3e-9
Score:  0.807
Data Source:  BioPlex,STRINGDB
PHF7
Tbio
Family:  Epigenetic
Novelty:  0.0925472
p_int:  0.999497338
p_ni:  0.000502662
Score:  0.167
Data Source:  BioPlex,STRINGDB
SCAMP1
Tbio
Novelty:  0.03293648
p_int:  0.999246308
p_ni:  0.000753692
p_wrong:  1e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.997569565
p_ni:  0.002430435
Score:  0.516
Data Source:  BioPlex,STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.997253225
p_ni:  0.002746751
p_wrong:  2.4e-8
Score:  0.403
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.99369963
p_ni:  0.006300254
p_wrong:  1.16e-7
Data Source:  BioPlex
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.993674452
p_ni:  0.006325321
p_wrong:  2.27e-7
Data Source:  BioPlex
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.993014985
p_ni:  0.005405099
p_wrong:  0.001579916
Score:  0.213
Data Source:  BioPlex,STRINGDB
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.985670444
p_ni:  0.014329509
p_wrong:  4.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (400)
Items per page:
1 – 5 of 400
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
0
9
99.2
2
4
0
9
99.2
5
3
0
3.1
99
5
3
0
3.1
99
HIV-1 infection
3
6
0
2.9
98.9
Items per page:
1 – 5 of 400
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
9
99.2
0
9
99.2
0
3.1
99
0
3.1
99
HIV-1 infection
0
2.9
98.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MHC class I polypeptide-related sequence B
715141
Cow
major histocompatibility class I related protein
533051
Pig
MHC class I polypeptide-related sequence B
100153163
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MHC class I polypeptide-related sequence B
Cow
major histocompatibility class I related protein
Pig
MHC class I polypeptide-related sequence B
Publication Statistics
PubMed Score 22.59
PubMed score by year
PubTator Score 1122.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title