MIB2
E3 ubiquitin-protein ligase MIB2
Protein Summary
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
- ENST00000355826
- ENSP00000348081
- ENSG00000197530
- ENST00000378712
- ENSP00000367984
- ENST00000505820
- ENSP00000426103
- ENST00000518681
- ENSP00000428264
- ENST00000520777
- ENSP00000428660
- SKD
- ZZANK1
- ZZZ5
- ZZANK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.79 | ||
transcription factor perturbation | 0.74 | ||
transcription factor | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.78 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.78 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0