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Tbio
MGST3
Microsomal glutathione S-transferase 3

Protein Summary
Description
Also functions as a glutathione peroxidase. This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367884
  • ENSP00000356859
  • ENSG00000143198
  • ENST00000367889
  • ENSP00000356864

Symbol
  • GST-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
cellular component
0.71
kinase perturbation
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.974243305
p_ni:  0.025756684
p_wrong:  1.1e-8
Data Source:  BioPlex
S100A13
Tbio
Novelty:  0.0283577
p_int:  0.96474326
p_ni:  0.031627444
p_wrong:  0.003629296
Score:  0.187
Data Source:  BioPlex,STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.958882583
p_ni:  0.041117417
Score:  0.179
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.944905699
p_ni:  0.055094301
Data Source:  BioPlex
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.94272354
p_ni:  0.05726753
p_wrong:  0.000008929
Data Source:  BioPlex
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.932257675
p_ni:  0.067742322
p_wrong:  2e-9
Data Source:  BioPlex
HSPA12A
Tbio
Novelty:  0.11999085
p_int:  0.893039902
p_ni:  0.106960096
p_wrong:  2e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.874442586
p_ni:  0.125557414
Data Source:  BioPlex
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.868289809
p_ni:  0.000130761
p_wrong:  0.131579431
Score:  0.189
Data Source:  BioPlex,STRINGDB
SVIP
Tbio
Novelty:  0.05269453
p_int:  0.844980828
p_ni:  0.114139787
p_wrong:  0.040879384
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (26)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
7
5
10
98.2
4
2
0
1.4
88.9
2
2
0
1.4
85
granulocyte count
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
10
98.2
0
1.4
88.9
0
1.4
85
granulocyte count
1
5.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 3
VGNC:6916
457477
Macaque
microsomal glutathione S-transferase 3
695275
Mouse
MGI:1913697
66447
Rat
RGD:1306373
289197
Dog
microsomal glutathione S-transferase 3
VGNC:53121
609050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 3
Macaque
microsomal glutathione S-transferase 3
Mouse
Rat
Dog
microsomal glutathione S-transferase 3
Publication Statistics
PubMed Score 33.56
PubMed score by year
PubTator Score 11.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title