MGST3
Microsomal glutathione S-transferase 3
Protein Summary
Also functions as a glutathione peroxidase. This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
- ENST00000367884
- ENSP00000356859
- ENSG00000143198
- ENST00000367889
- ENSP00000356864
- GST-III
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
transcription factor binding site profile | 0.82 | ||
transcription factor perturbation | 0.8 | ||
cellular component | 0.71 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.94 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 113 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.94 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 113 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0