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Tbio
MGST2
Microsomal glutathione S-transferase 2

Protein Summary
Description
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265498
  • ENSP00000265498
  • ENSG00000085871
  • ENST00000503816
  • ENSP00000423008
  • ENST00000506797
  • ENSP00000424278
  • ENST00000616265
  • ENSP00000482639

Symbol
  • GST2
  • GST2
  • MGST-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.71
transcription factor perturbation
0.68
transcription factor binding site profile
0.61
biological process
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
RELL2
Tbio
Novelty:  0.59290726
p_int:  0.999522281
p_ni:  0.000107057
p_wrong:  0.000370662
Score:  0.269
Data Source:  BioPlex,STRINGDB
APOD
Tbio
Novelty:  0.0031899
p_int:  0.899985026
p_ni:  0.099486414
p_wrong:  0.00052856
Data Source:  BioPlex
CYP26B1
Tchem
Novelty:  0.00990332
p_int:  0.864742985
p_ni:  0.000009198
p_wrong:  0.135247817
Data Source:  BioPlex
CST8
Tbio
Novelty:  0.02316886
p_int:  0.845026204
p_ni:  0.148071006
p_wrong:  0.00690279
Data Source:  BioPlex
MGST1
Tbio
Family:  Enzyme
Novelty:  0.00681882
Score:  0.93
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.9
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.863
Data Source:  STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
Score:  0.835
Data Source:  STRINGDB
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
Score:  0.806
Data Source:  STRINGDB
GSTO2
Tbio
Family:  Enzyme
Novelty:  0.01836256
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (30)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
87.7
intelligence
2
2
2
72.1
1
1
1
60.2
mathematical ability
1
1
1
59
cognitive function measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
87.7
intelligence
2
72.1
1
60.2
mathematical ability
1
59
cognitive function measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 2
VGNC:2070
737085
Macaque
microsomal glutathione S-transferase 2
697983
Mouse
MGI:2448481
211666
Rat
RGD:1311218
295037
Dog
microsomal glutathione S-transferase 2
VGNC:54328
476078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 2
Macaque
microsomal glutathione S-transferase 2
Mouse
Rat
Dog
microsomal glutathione S-transferase 2
Publication Statistics
PubMed Score 20.96
PubMed score by year
PubTator Score 10.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title