MGRN1
E3 ubiquitin-protein ligase MGRN1
Protein Summary
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
- ENST00000262370
- ENSP00000262370
- ENSG00000102858
- ENST00000399577
- ENSP00000382487
- ENST00000415496
- ENSP00000393311
- ENST00000586183
- ENSP00000465860
- ENST00000588994
- ENSP00000468819
- KIAA0544
- RNF156
- RNF156
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.89 | ||
transcription factor | 0.74 | ||
cell type or tissue | 0.66 | ||
cellular component | 0.63 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.86 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 214 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.86 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 214 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0