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Tdark
MGAT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

Protein Summary
Description
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000548651
  • ENSP00000447253
  • ENSG00000182050
  • ENST00000552808
  • ENSP00000446647
  • ENST00000611864
  • ENSP00000481096
  • ENST00000620241
  • ENSP00000477650
  • ENST00000621808
  • ENSP00000478300
  • ENST00000636211
  • ENSP00000489618
  • ENSG00000283530
  • ENST00000636626
  • ENSP00000490784
  • ENST00000637362
  • ENSP00000490416
  • ENST00000637661
  • ENSP00000489751
  • ENST00000638103
  • ENSP00000490547
  • ENST00000643295
  • ENSP00000495724
  • ENSG00000285137
  • ENST00000644829
  • ENSP00000496716
  • ENST00000645144
  • ENSP00000494369
  • ENST00000646486
  • ENSP00000495039
  • ENST00000646655
  • ENSP00000494764

Symbol
  • GNTIVH
  • HGNT-IV-H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
pathway
0.8
cell type or tissue
0.72
cellular component
0.7
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
GAL
Tbio
Novelty:  0.0005132
p_int:  0.999985192
p_ni:  0.000002145
p_wrong:  0.000012664
Score:  0.272
Data Source:  BioPlex,STRINGDB
METRN
Tbio
Novelty:  0.03357541
p_int:  0.999943598
p_ni:  0.000049896
p_wrong:  0.000006506
Data Source:  BioPlex
PCSK1N
Tbio
Novelty:  0.02656799
p_int:  0.999928258
p_ni:  0.000069229
p_wrong:  0.000002513
Score:  0.179
Data Source:  BioPlex,STRINGDB
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
p_int:  0.999183131
p_ni:  0.000780333
p_wrong:  0.000036536
Data Source:  BioPlex
HAPLN3
Tbio
Novelty:  0.19545048
p_int:  0.998106593
p_ni:  0.0018934
p_wrong:  7e-9
Data Source:  BioPlex
ITGA2
Tbio
Novelty:  0.0013482
p_int:  0.997838237
p_ni:  0.00216161
p_wrong:  1.53e-7
Data Source:  BioPlex
DSE
Tbio
Family:  Enzyme
Novelty:  0.02945465
p_int:  0.996578209
p_ni:  0.003421318
p_wrong:  4.73e-7
Data Source:  BioPlex
NMU
Tbio
Novelty:  0.00326109
p_int:  0.993833123
p_ni:  0.006164772
p_wrong:  0.000002106
Data Source:  BioPlex
GLT8D2
Tbio
Family:  Enzyme
Novelty:  0.79488367
p_int:  0.988226502
p_ni:  0.006722108
p_wrong:  0.005051391
Data Source:  BioPlex
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.98800922
p_ni:  0.01199077
p_wrong:  1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-Glycan antennae elongation
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-Glycan antennae elongation
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
1
1
1
15.8
smoking behavior
1
1
1
15.8
mathematical ability
1
1
1
2.7
mathematical ability
1
1
1
2.7
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
1
15.8
smoking behavior
1
15.8
mathematical ability
1
2.7
mathematical ability
1
2.7
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MGAT4 family member C
700450
Mouse
MGI:1914819
67569
Rat
RGD:1307871
299756
Dog
MGAT4 family member C
VGNC:54326
475418
Horse
MGAT4 family member C
VGNC:20160
100051064
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MGAT4 family member C
Mouse
Rat
Dog
MGAT4 family member C
Horse
MGAT4 family member C
Publication Statistics
PubMed Score 4.91
PubMed score by year
PubTator Score 2.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title