You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MGAT3
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Protein Summary
Description
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (PubMed:19403558). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location (PubMed:19403558). Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341184
  • ENSP00000345270
  • ENSG00000128268

Symbol
  • GGNT3
  • GNT3
  • GNT-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
tissue sample
0.7
virus perturbation
0.68
cellular component
0.65
transcription factor
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (57)
MGAT4B
Tbio
Family:  Enzyme
Novelty:  0.11244606
Score:  0.983
Data Source:  STRINGDB
MGAT4A
Tbio
Family:  Enzyme
Novelty:  0.05868941
Score:  0.982
Data Source:  STRINGDB
MGAT2
Tchem
Family:  Enzyme
Novelty:  0.02440696
Score:  0.98
Data Source:  STRINGDB
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
Score:  0.975
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.965
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.919
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.919
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.919
Data Source:  STRINGDB
MGAT4D
Tdark
Family:  Enzyme
Novelty:  1.29575367
Score:  0.9
Data Source:  STRINGDB
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
Score:  0.892
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan antennae elongation in the medial/trans-Golgi
Reactome
Post-translational protein modification
Reactome
Reactions specific to the hybrid N-glycan synthesis pathway
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan antennae elongation in the medial/trans-Golgi
Post-translational protein modification
Reactions specific to the hybrid N-glycan synthesis pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
5.9
89.6
serum IgG glycosylation measurement
2
2
3
87.8
intelligence
5
10
7
5.6
79.6
mathematical ability
3
2
4
72.6
self reported educational attainment
4
5
4
5.6
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
5.9
89.6
serum IgG glycosylation measurement
3
87.8
intelligence
7
5.6
79.6
mathematical ability
4
72.6
self reported educational attainment
4
5.6
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
VGNC:14781
470218
Macaque
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
703643
Mouse
MGI:104532
17309
Rat
RGD:3084
29582
Dog
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
VGNC:54526
481244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Macaque
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Publication Statistics
PubMed Score 22.02
PubMed score by year
PubTator Score 86.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title