You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MGAT2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Protein Summary
Description
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305386
  • ENSP00000307423
  • ENSG00000168282

Symbol
  • GNT2
  • CDG2A
  • CDGS2
  • GNT-II
  • GLCNACTII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.86
kinase perturbation
0.84
transcription factor binding site profile
0.82
phenotype
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.37   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.37   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 403
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (403)
CHEMBL2376303
Rendered image for CHEMBL2376303
CHEMBL2376321
Rendered image for CHEMBL2376321
CHEMBL2376325
Rendered image for CHEMBL2376325
CHEMBL3736366
Rendered image for CHEMBL3736366
CHEMBL3736092
Rendered image for CHEMBL3736092
CHEMBL3734770
Rendered image for CHEMBL3734770
CHEMBL3325734,CHEMBL3545611
Rendered image for CHEMBL3325734,CHEMBL3545611
CHEMBL2441600
Rendered image for CHEMBL2441600
BDBM152808::US8993568, 2
Rendered image for BDBM152808::US8993568, 2
CHEMBL2441599
Rendered image for CHEMBL2441599
Protein-Protein Interactions (60)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.990627875
p_ni:  0.009372125
Score:  0.212
Data Source:  BioPlex,STRINGDB
MAN1A1
Tbio
Family:  Enzyme
Novelty:  0.00645679
p_int:  0.979652051
p_ni:  0.020347949
Score:  0.23
Data Source:  BioPlex,STRINGDB
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.768838023
p_ni:  0.231161977
Score:  0.189
Data Source:  BioPlex,STRINGDB
MGAT3
Tchem
Family:  Enzyme
Novelty:  0.04261352
Score:  0.98
Data Source:  STRINGDB
MGAT4B
Tbio
Family:  Enzyme
Novelty:  0.11244606
Score:  0.976
Data Source:  STRINGDB
MGAT4A
Tbio
Family:  Enzyme
Novelty:  0.05868941
Score:  0.976
Data Source:  STRINGDB
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
Score:  0.967
Data Source:  STRINGDB
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
Score:  0.966
Data Source:  STRINGDB
MGAT4D
Tdark
Family:  Enzyme
Novelty:  1.29575367
Score:  0.944
Data Source:  STRINGDB
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Disease
Diseases associated with N-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384966
217664
Rat
RGD:620098
94273
Dog
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
VGNC:50544
480312
Horse
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:7045]
Cow
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
VGNC:54626
101906103
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Horse
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:7045]
Cow
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Publication Statistics
PubMed Score 40.37
PubMed score by year
PubTator Score 41.49
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title