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Tchem
MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Protein Summary
Description
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307826
  • ENSP00000311888
  • ENSG00000131446
  • ENST00000333055
  • ENSP00000332073
  • ENST00000393340
  • ENSP00000377010
  • ENST00000427865
  • ENSP00000402838
  • ENST00000446023
  • ENSP00000404718

Symbol
  • GGNT1
  • GLCT1
  • GLYT1
  • MGAT
  • GnTI
  • MGAT
  • GLCT1
  • GLYT1
  • GNT-1
  • GNT-I
  • GLCNAC-TI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
co-expressed gene
0.85
kinase perturbation
0.84
transcription factor binding site profile
0.77
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.9   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.9   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (92)
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.968152869
p_ni:  0.031847131
Score:  0.26
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.964491255
p_ni:  0.035508745
Data Source:  BioPlex
RELL1
Tbio
Novelty:  0.28949625
p_int:  0.946867958
p_ni:  0.053132042
Score:  0.219
Data Source:  BioPlex,STRINGDB
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.856478285
p_ni:  0.143521715
Score:  0.752
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.751160735
p_ni:  0.248839265
Data Source:  BioPlex
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
Score:  0.981
Data Source:  STRINGDB
MAN1A1
Tbio
Family:  Enzyme
Novelty:  0.00645679
Score:  0.969
Data Source:  STRINGDB
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
Score:  0.968
Data Source:  STRINGDB
MAN1A2
Tbio
Family:  Enzyme
Novelty:  0.15637608
Score:  0.962
Data Source:  STRINGDB
MAN1C1
Tbio
Family:  Enzyme
Novelty:  0.13017812
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming and elongation in the cis-Golgi
Reactome
Post-translational protein modification
Reactome
Transport to the Golgi and subsequent modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming and elongation in the cis-Golgi
Post-translational protein modification
Transport to the Golgi and subsequent modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
31.4
apolipoprotein A 1 measurement
1
1
1
26.6
1
1
1
14.2
left atrial function
1
1
1
9.1
high density lipoprotein cholesterol measurement
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
31.4
apolipoprotein A 1 measurement
1
26.6
1
14.2
left atrial function
1
9.1
high density lipoprotein cholesterol measurement
1
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
VGNC:8628
462340
Mouse
MGI:96973
17308
Rat
RGD:620097
81519
Dog
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
491674
Cow
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
VGNC:54623
534248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Cow
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Publication Statistics
PubMed Score 97.90
PubMed score by year
PubTator Score 70.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title