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Tbio
MGARP
Protein MGARP

Protein Summary
Description
Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398955
  • ENSP00000381928
  • ENSG00000137463

Symbol
  • C4orf49
  • CESP1
  • HUMMR
  • OSAP
  • OSAP
  • HUMMR
  • CESP-1
  • C4orf49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
virus perturbation
0.72
cell type or tissue
0.69
cellular component
0.67
biological process
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.89   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.89   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.999895638
p_ni:  0.000104362
Data Source:  BioPlex
TSC22D2
Tdark
Family:  TF
Novelty:  0.30718123
p_int:  0.999292745
p_ni:  0.000701809
p_wrong:  0.000005445
Data Source:  BioPlex
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.999180225
p_ni:  0.000810658
p_wrong:  0.000009117
Data Source:  BioPlex
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.998337492
p_ni:  0.0011895
p_wrong:  0.000473008
Data Source:  BioPlex
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.997484067
p_ni:  0.002512677
p_wrong:  0.000003256
Data Source:  BioPlex
SFXN3
Tbio
Novelty:  0.18698456
p_int:  0.997235871
p_ni:  0.002763944
p_wrong:  1.85e-7
Data Source:  BioPlex
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.991777638
p_ni:  0.008197634
p_wrong:  0.000024728
Data Source:  BioPlex
SLC25A20
Tbio
Family:  Transporter
Novelty:  0.00503518
p_int:  0.990692383
p_ni:  0.009306741
p_wrong:  8.76e-7
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.987049292
p_ni:  0.012950708
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.98512956
p_ni:  0.014835914
p_wrong:  0.000034526
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.6
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.6
11.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitochondria localized glutamic acid rich protein
697003
Mouse
MGI:1914999
67749
Rat
RGD:1586369
689931
Dog
mitochondria localized glutamic acid rich protein
VGNC:43212
607964
Horse
mitochondria localized glutamic acid rich protein
VGNC:50719
100063365
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitochondria localized glutamic acid rich protein
Mouse
Rat
Dog
mitochondria localized glutamic acid rich protein
Horse
mitochondria localized glutamic acid rich protein
Publication Statistics
PubMed Score 38.89
PubMed score by year
PubTator Score 13.40
PubTator score by year
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Related Publications
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PMID
Year
Title