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Tbio
MGA
MAX gene-associated protein

Protein Summary
Description
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219905
  • ENSP00000219905
  • ENSG00000174197
  • ENST00000545763
  • ENSP00000442467
  • ENST00000566586
  • ENSP00000456141
  • ENST00000570161
  • ENSP00000457035

Symbol
  • KIAA0518
  • MAD5
  • MAD5
  • MXD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor
0.82
transcription factor perturbation
0.68
kinase perturbation
0.66
co-expressed gene
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.36   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.36   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0