You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
MFSD5
Molybdate-anion transporter

Protein Summary
Description
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329548
  • ENSP00000332624
  • ENSG00000182544
  • ENST00000534842
  • ENSP00000442688

Symbol
  • hsMOT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.84
transcription factor binding site profile
0.68
transcription factor
0.64
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999713239
p_ni:  0.000286761
Score:  0.16
Data Source:  BioPlex,STRINGDB
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.999500968
p_ni:  0.000499032
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999344445
p_ni:  0.000655554
p_wrong:  1e-9
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.998407213
p_ni:  0.001591894
p_wrong:  8.93e-7
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.997637411
p_ni:  0.00236052
p_wrong:  0.000002068
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.997179887
p_ni:  0.002818265
p_wrong:  0.000001847
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.984900075
p_ni:  0.004658539
p_wrong:  0.010441387
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.984900075
p_ni:  0.004658539
p_wrong:  0.010441387
Data Source:  BioPlex
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.976719849
p_ni:  0.001396969
p_wrong:  0.021883183
Data Source:  BioPlex
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.974298478
p_ni:  0.025170488
p_wrong:  0.000531033
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
4
3
5
85.7
alkaline phosphatase measurement
2
1
1
8.8
82.8
body height
1
1
1
79.5
heel bone mineral density
1
1
1
69.3
spine bone mineral density
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
5
85.7
alkaline phosphatase measurement
1
8.8
82.8
body height
1
79.5
heel bone mineral density
1
69.3
spine bone mineral density
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 5
VGNC:13219
467001
Macaque
major facilitator superfamily domain containing 5
702021
Mouse
MGI:2145901
106073
Rat
RGD:1305138
315329
Dog
major facilitator superfamily domain containing 5
VGNC:43204
607891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 5
Macaque
major facilitator superfamily domain containing 5
Mouse
Rat
Dog
major facilitator superfamily domain containing 5
Publication Statistics
PubMed Score 2.45
PubMed score by year
PubTator Score 1.66
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title