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Tdark
MFSD4A
Major facilitator superfamily domain-containing protein 4A

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.53   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.53   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.999944602
p_ni:  0.000055379
p_wrong:  1.9e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
CYSTM1
Tdark
Novelty:  1.37759108
p_int:  0.999355655
p_ni:  0.000124259
p_wrong:  0.000520085
Score:  0.415
Data Source:  BioPlex,STRINGDB
ATP5S
Tbio
Family:  Enzyme
Novelty:  0.15637839
p_int:  0.998168142
p_ni:  0.000257407
p_wrong:  0.001574451
Score:  0.228
Data Source:  BioPlex,STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
p_int:  0.99692175
p_ni:  0.003056347
p_wrong:  0.000021903
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.986325942
p_ni:  0.013673765
p_wrong:  2.93e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.94359582
p_ni:  0.056404175
p_wrong:  4e-9
Data Source:  BioPlex
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
p_int:  0.93497856
p_ni:  0.06502144
Data Source:  BioPlex
HIP1R
Tbio
Novelty:  0.02502713
p_int:  0.908881724
p_ni:  0.091118274
p_wrong:  2e-9
Data Source:  BioPlex
SLC7A2
Tbio
Family:  Transporter
Novelty:  0.02262224
p_int:  0.902097649
p_ni:  0.097902344
p_wrong:  6e-9
Score:  0.26
Data Source:  BioPlex,STRINGDB
APOB
Tchem
Novelty:  0.00008247
p_int:  0.830105205
p_ni:  0.169894795
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
5
5
5
90.4
basophil count
3
3
3
89.6
sex hormone-binding globulin measurement
2
1
2
52
basophil percentage of granulocytes
1
1
1
42.3
monocyte percentage of leukocytes
1
1
1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
5
90.4
basophil count
3
89.6
sex hormone-binding globulin measurement
2
52
basophil percentage of granulocytes
1
42.3
monocyte percentage of leukocytes
1
32.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 4A
VGNC:11534
743171
Macaque
major facilitator superfamily domain containing 4A
697813
Mouse
MGI:2442786
213006
Rat
RGD:1566090
498228
Dog
major facilitator superfamily domain containing 4A
VGNC:43203
478943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 4A
Macaque
major facilitator superfamily domain containing 4A
Mouse
Rat
Dog
major facilitator superfamily domain containing 4A
Publication Statistics
PubMed Score 2.53
PubMed score by year
PubTator Score 0.58
PubTator score by year
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Related Publications
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PMID
Year
Title