Protein Summary
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress ...more
- ENST00000235329
- ENSP00000235329
- ENSG00000116688
- ENST00000444836
- ENSP00000416338
- CPRP1
- KIAA0214
- HSG
- MARF
- CMT2A
- CPRP1
- CMT2A2
- HMSN6A
- CMT2A2A
- CMT2A2B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.95 | ||
co-expressed gene | 0.93 | ||
kinase perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
virus perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 864.34 (req: < 5)
Gene RIFs: 158 (req: <= 3)
Antibodies: 643 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 864.34 (req: >= 5)
Gene RIFs: 158 (req: > 3)
Antibodies: 643 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (202)
MFN1
Novelty: 0.00372574
p_int: 0.99999989
p_ni: 1.08e-7
p_wrong: 2e-9
Score: 0.947
Data Source: BioPlex,STRINGDB
REEP5
Novelty: 0.00160455
p_int: 0.99999968
p_ni: 3.18e-7
p_wrong: 1e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
GHITM
Novelty: 0.00360652
p_int: 0.999999666
p_ni: 3.34e-7
Score: 0.458
Data Source: BioPlex,STRINGDB
MARCH5
Family: Epigenetic
Novelty: 0.02702094
p_int: 0.999634738
p_ni: 0.00036522
p_wrong: 4.1e-8
Score: 0.916
Data Source: BioPlex,STRINGDB
THY1
Novelty: 0.00032846
p_int: 0.991002024
p_ni: 0.008620313
p_wrong: 0.000377663
Data Source: BioPlex
VSIG1
Novelty: 0.15442611
p_int: 0.970657573
p_ni: 0.022456243
p_wrong: 0.006886184
Score: 0.222
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (7)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Reactome | Macroautophagy | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Macroautophagy | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (3)
Components (6)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 4 | 4 | 3 | 2.2 | 97.7 | ||||
platelet crit | 2 | 2 | 2 | 95 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 72.6 | |||||
mitochondrial DNA measurement | 1 | 1 | 1 | 63.7 | |||||
homocysteine measurement | 1 | 2 | 2 | 53.2 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 3 | 2.2 | 97.7 | ||||
platelet crit | 2 | 95 | |||||
eosinophil percentage of leukocytes | 3 | 72.6 | |||||
mitochondrial DNA measurement | 1 | 63.7 | |||||
homocysteine measurement | 2 | 53.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | mitofusin 2 | VGNC:1318 | 457958 | |||||
Mouse | MGI:2442230 | 170731 | ||||||
Rat | RGD:628843 | 64476 | ||||||
Dog | mitofusin 2 | VGNC:43193 | 487439 | |||||
Horse | mitofusin 2 | VGNC:20145 | 100055966 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | mitofusin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitofusin 2 | |||||
Horse | mitofusin 2 | |||||
Publication Statistics
PubMed Score 864.34
PubMed score by year
PubTator Score 371.18
PubTator score by year
Related Publications
Text Mined References (180)
GeneRif Annotations (158)
Items per page:
0 of 0
PMID | Year | Title |
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