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Tbio
MFN2
Mitofusin-2

Protein Summary
Description
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235329
  • ENSP00000235329
  • ENSG00000116688
  • ENST00000444836
  • ENSP00000416338

Symbol
  • CPRP1
  • KIAA0214
  • HSG
  • MARF
  • CMT2A
  • CPRP1
  • CMT2A2
  • HMSN6A
  • CMT2A2A
  • CMT2A2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
co-expressed gene
0.93
kinase perturbation
0.93
transcription factor perturbation
0.91
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1040.78   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 643   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1040.78   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 643   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
MFN1
Tbio
Novelty:  0.00372574
p_int:  0.99999989
p_ni:  1.08e-7
p_wrong:  2e-9
Score:  0.947
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.99999968
p_ni:  3.18e-7
p_wrong:  1e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.999999666
p_ni:  3.34e-7
Score:  0.458
Data Source:  BioPlex,STRINGDB
MARCH5
Tbio
Family:  Epigenetic
Novelty:  0.02702094
p_int:  0.999634738
p_ni:  0.00036522
p_wrong:  4.1e-8
Score:  0.916
Data Source:  BioPlex,STRINGDB
THY1
Tbio
Novelty:  0.00032846
p_int:  0.991002024
p_ni:  0.008620313
p_wrong:  0.000377663
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.970657573
p_ni:  0.022456243
p_wrong:  0.006886184
Score:  0.222
Data Source:  BioPlex,STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.997
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.99
Data Source:  STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.978
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Factors involved in megakaryocyte development and platelet production
Hemostasis
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
6
5
2.2
97.6
mitochondrial DNA measurement
2
2
2
89.2
platelet crit
2
2
2
86.4
eosinophil count
4
2
4
72.7
homocysteine measurement
1
2
2
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
2.2
97.6
mitochondrial DNA measurement
2
89.2
platelet crit
2
86.4
eosinophil count
4
72.7
homocysteine measurement
2
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitofusin 2
VGNC:1318
457958
Mouse
MGI:2442230
170731
Rat
RGD:628843
64476
Dog
mitofusin 2
VGNC:43193
487439
Horse
mitofusin 2
VGNC:20145
100055966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitofusin 2
Mouse
Rat
Dog
mitofusin 2
Horse
mitofusin 2
Publication Statistics
PubMed Score 1040.78
PubMed score by year
PubTator Score 371.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title