Tbio MFN1 Mitofusin-1

Protein Summary

Description

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303). The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IWA4
• A0A0C4DFN1
• B2RAR1
• D3DNR6
• O15323
• O60639
• Q9BZB5
• Q9NWQ2

Gene Name

• MFN1

Ensembl ID

• ENST00000263969
• ENSP00000263969
• ENSG00000171109
• ENST00000357390
• ENSP00000349963
• ENST00000471841
• ENSP00000420617

Symbol

• hfzo1
• hfzo2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
disease perturbation	0.99
transcription factor perturbation	0.94
molecular function	0.91
histone modification site profile	0.88

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Mitofusin-1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Mitofusin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.94   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.94   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0