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Tbio
MFHAS1
Malignant fibrous histiocytoma-amplified sequence 1

Protein Summary
Description
Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276282
  • ENSP00000276282
  • ENSG00000147324

Symbol
  • MASL1
  • MASL1
  • ROCO4
  • LRRC65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
microRNA
0.8
disease perturbation
0.79
PubMedID
0.72
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.998340024
p_ni:  0.001659934
p_wrong:  4.2e-8
Score:  0.237
Data Source:  BioPlex,STRINGDB
CLDN23
Tbio
Novelty:  0.12349944
Score:  0.93
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.902
Data Source:  STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
Score:  0.693
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ARL11
Tbio
Family:  Enzyme
Novelty:  0.04033783
Score:  0.682
Data Source:  STRINGDB
DAPK1
Tchem
Family:  Kinase
Novelty:  0.0031894
Score:  0.621
Data Source:  STRINGDB
PJA2
Tbio
Family:  Enzyme
Novelty:  0.13275213
Score:  0.562
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
21
21
96.6
alkaline phosphatase measurement
1
1
1
85.9
glomerular filtration rate
2
2
2
83
waist-hip ratio
1
14
14
80
BMI-adjusted waist circumference
2
19
21
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
21
96.6
alkaline phosphatase measurement
1
85.9
glomerular filtration rate
2
83
waist-hip ratio
14
80
BMI-adjusted waist circumference
21
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
malignant fibrous histiocytoma amplified sequence 1
472694
Macaque
malignant fibrous histiocytoma amplified sequence 1
699633
Mouse
MGI:1098644
52065
Rat
RGD:1308812
306508
Dog
malignant fibrous histiocytoma amplified sequence 1
475604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
malignant fibrous histiocytoma amplified sequence 1
Macaque
malignant fibrous histiocytoma amplified sequence 1
Mouse
Rat
Dog
malignant fibrous histiocytoma amplified sequence 1
Publication Statistics
PubMed Score 14.21
PubMed score by year
PubTator Score 8.24
PubTator score by year
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Related Publications
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PMID
Year
Title