Tbio MFGE8 Lactadherin

Protein Summary

Description

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin is the main constituent of aortic medial amyloid. This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q08431
• B2R6M7
• F5GZN3
• Q53FU9
• Q7Z3D2
• Q9BTL9

Gene Name

• MFGE8

Ensembl ID

• ENST00000268150
• ENSP00000268150
• ENSG00000140545
• ENST00000268151
• ENSP00000268151
• ENST00000542878
• ENSP00000444332
• ENST00000566497
• ENSP00000456281

Symbol

• BA46
• HMFG
• MFGM
• SED1
• hP47
• EDIL1
• MFG-E8
• SPAG10
• OAcGD3S
• HsT19888

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
transcription factor perturbation	0.98
kinase perturbation	0.95
PubMedID	0.83
small molecule perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Lactadherin

Protein / Receptor / Lactadherin

Protein / Hydrolase / Lactadherin

Protein / Cell Adhesion Molecule / Lactadherin

DTO Classes

Protein / Enzyme / Hydrolase / Lactadherin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 633   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0