You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MFGE8
Lactadherin

Protein Summary
Description
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin is the main constituent of aortic medial amyloid. This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268150
  • ENSP00000268150
  • ENSG00000140545
  • ENST00000268151
  • ENSP00000268151
  • ENST00000542878
  • ENSP00000444332
  • ENST00000566497
  • ENSP00000456281

Symbol
  • BA46
  • HMFG
  • MFGM
  • SED1
  • hP47
  • EDIL1
  • MFG-E8
  • SPAG10
  • OAcGD3S
  • HsT19888
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.98
kinase perturbation
0.95
PubMedID
0.83
small molecule perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1002.91   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
ITGB5
Tbio
Novelty:  0.01455909
p_int:  0.999904409
p_ni:  0.000095586
p_wrong:  5e-9
Score:  0.774
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.88632382
p_ni:  0.11367618
Data Source:  BioPlex
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.866378624
p_ni:  0.133621376
Score:  0.219
Data Source:  BioPlex,STRINGDB
GAS6
Tbio
Novelty:  0.00297606
Score:  0.975
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.95
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.938
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.935
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.932
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.932
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
10
12
99.2
appendicular lean mass
5
5
8
96.8
body fat distribution
3
2
12
95.8
BMI-adjusted hip circumference
3
26
27
94.5
BMI-adjusted waist circumference
5
10
15
91.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
12
99.2
appendicular lean mass
8
96.8
body fat distribution
12
95.8
BMI-adjusted hip circumference
27
94.5
BMI-adjusted waist circumference
15
91.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
milk fat globule-EGF factor 8 protein
453631
Mouse
MGI:102768
17304
Rat
RGD:3083
25277
Dog
milk fat globule-EGF factor 8 protein
VGNC:53186
488730
Horse
milk fat globule-EGF factor 8 protein [Source:HGNC Symbol;Acc:HGNC:7036]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
milk fat globule-EGF factor 8 protein
Mouse
Rat
Dog
milk fat globule-EGF factor 8 protein
Horse
milk fat globule-EGF factor 8 protein [Source:HGNC Symbol;Acc:HGNC:7036]
Publication Statistics
PubMed Score 1002.91
PubMed score by year
PubTator Score 704.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title