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Tbio
MFAP4
Microfibril-associated glycoprotein 4

Protein Summary
Description
Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954). This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299610
  • ENSP00000299610
  • ENSG00000166482
  • ENST00000395592
  • ENSP00000378957
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
tissue sample
0.59
small molecule perturbation
0.57
PubMedID
0.53
cell line
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.47   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.47   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
AES
Tbio
Novelty:  0.00818499
p_int:  0.999999925
p_ni:  7.5e-8
Data Source:  BioPlex
TLE2
Tbio
Novelty:  0.03922169
p_int:  0.999999736
p_ni:  2.64e-7
Data Source:  BioPlex
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.999999622
p_ni:  3.79e-7
Data Source:  BioPlex
SSBP3
Tbio
Novelty:  0.01955714
p_int:  0.999999468
p_ni:  5.32e-7
Data Source:  BioPlex
TBC1D5
Tbio
Novelty:  0.11547525
p_int:  0.999999446
p_ni:  5.54e-7
Data Source:  BioPlex
TLE4
Tbio
Novelty:  0.02094922
p_int:  0.999999349
p_ni:  6.51e-7
Data Source:  BioPlex
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.99999933
p_ni:  6.7e-7
Data Source:  BioPlex
LDB1
Tbio
Novelty:  0.01110112
p_int:  0.999995911
p_ni:  0.000004089
Data Source:  BioPlex
PPHLN1
Tbio
Novelty:  0.21311177
p_int:  0.999984752
p_ni:  0.000015248
Data Source:  BioPlex
SSBP2
Tbio
Novelty:  0.06546999
p_int:  0.999983373
p_ni:  0.000016623
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
2
3
72.4
diastolic blood pressure
1
1
1
59.9
mathematical ability
1
1
1
53.7
creatinine measurement
1
1
1
31.1
glomerular filtration rate
1
1
1
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
72.4
diastolic blood pressure
1
59.9
mathematical ability
1
53.7
creatinine measurement
1
31.1
glomerular filtration rate
1
30
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
microfibril associated protein 4
710893
Mouse
MGI:1342276
76293
Dog
microfibril associated protein 4
VGNC:43190
489531
Horse
microfibril associated protein 4
VGNC:20142
100073173
Cow
microfibril associated protein 4
VGNC:31424
286766
Species
Name
OMA
EggNOG
Inparanoid
Macaque
microfibril associated protein 4
Mouse
Dog
microfibril associated protein 4
Horse
microfibril associated protein 4
Cow
microfibril associated protein 4
Publication Statistics
PubMed Score 60.47
PubMed score by year
PubTator Score 24.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title