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Tdark
MFAP3
Microfibril-associated glycoprotein 3

Protein Summary
Description
Component of the elastin-associated microfibrils.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322602
  • ENSP00000322956
  • ENSG00000037749
  • ENST00000439768
  • ENSP00000414219
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.84
microRNA
0.78
disease perturbation
0.74
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999308707
p_ni:  0.000691292
Data Source:  BioPlex
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.996270276
p_ni:  0.00372971
p_wrong:  1.4e-8
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.995749206
p_ni:  0.004250794
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.994710783
p_ni:  0.005289216
p_wrong:  1e-9
Data Source:  BioPlex
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.993218228
p_ni:  0.006781772
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.993091915
p_ni:  0.006908085
Data Source:  BioPlex
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.991299955
p_ni:  0.008700045
Data Source:  BioPlex
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.988593897
p_ni:  0.011404184
p_wrong:  0.000001919
Data Source:  BioPlex
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.987574607
p_ni:  0.012425362
p_wrong:  3.2e-8
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.987450438
p_ni:  0.012549562
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
6
10
91.4
red blood cell distribution width
3
2
3
88
comparative body size at age 10, self-reported
1
1
1
73.9
7
3
1
1.1
60.2
1
2
0
1.1
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
10
91.4
red blood cell distribution width
3
88
comparative body size at age 10, self-reported
1
73.9
1
1.1
60.2
0
1.1
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microfibril associated protein 3
VGNC:4087
744007
Macaque
microfibril associated protein 3
713265
Mouse
MGI:1924068
216760
Rat
RGD:1359463
287299
Dog
microfibril associated protein 3
VGNC:43188
489166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microfibril associated protein 3
Macaque
microfibril associated protein 3
Mouse
Rat
Dog
microfibril associated protein 3
Publication Statistics
PubMed Score 1.93
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title