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Tbio
METTL7B
Methyltransferase-like protein 7B

Protein Summary
Description
Probable methyltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394252
  • ENSP00000377796
  • ENSG00000170439

Symbol
  • ALDI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
kinase perturbation
0.84
cell type or tissue
0.8
tissue sample
0.65
histone modification site profile
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.999981318
p_ni:  0.000018561
p_wrong:  1.22e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999942679
p_ni:  0.000057192
p_wrong:  1.29e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.933323896
p_ni:  0.002779318
p_wrong:  0.063896785
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.835975207
p_ni:  0.001861327
p_wrong:  0.162163466
Score:  0.153
Data Source:  BioPlex,STRINGDB
ADAM30
Tdark
Family:  Enzyme
Novelty:  0.25395428
p_int:  0.823413063
p_ni:  0.003375825
p_wrong:  0.173211113
Score:  0.228
Data Source:  BioPlex,STRINGDB
OCEL1
Tdark
Novelty:  0.44973795
Score:  0.597
Data Source:  STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
Score:  0.584
Data Source:  STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
Score:  0.579
Data Source:  STRINGDB
KRBOX1
Tdark
Novelty:  3.9375
Score:  0.571
Data Source:  STRINGDB
PLPP3
Tbio
Family:  Enzyme
Novelty:  0.01655047
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
3
13.8
96.4
Myopia
3
2
0
1.3
93
age at onset
1
1
0
13.8
83.1
Abnormality of refraction
1
1
1
53.3
atrophic macular degeneration
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
13.8
96.4
Myopia
0
1.3
93
age at onset
0
13.8
83.1
Abnormality of refraction
1
53.3
atrophic macular degeneration
0
1.2
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
methyltransferase like 7B
709549
Mouse
MGI:1918914
71664
Rat
RGD:1305205
366792
Dog
methyltransferase like 7B
VGNC:43181
474390
Cow
methyltransferase like 7B
VGNC:31416
506952
Species
Name
OMA
EggNOG
Inparanoid
Macaque
methyltransferase like 7B
Mouse
Rat
Dog
methyltransferase like 7B
Cow
methyltransferase like 7B
Publication Statistics
PubMed Score 17.06
PubMed score by year
PubTator Score 8.28
PubTator score by year
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Related Publications
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PMID
Year
Title