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Tdark
METTL6
Methyltransferase-like protein 6

Protein Summary
Description
Probable methyltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383789
  • ENSP00000373299
  • ENSG00000206562
  • ENST00000383790
  • ENSP00000373300
  • ENST00000443029
  • ENSP00000407613
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
histone modification site profile
0.88
transcription factor binding site profile
0.79
tissue sample
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.999996844
p_ni:  0.000003156
Score:  0.305
Data Source:  BioPlex,STRINGDB
WNK1
Tchem
Family:  Kinase
Novelty:  0.00270535
p_int:  0.999977392
p_ni:  0.000022608
Score:  0.219
Data Source:  BioPlex,STRINGDB
STIM1
Tbio
Novelty:  0.00116516
p_int:  0.999933537
p_ni:  0.000066463
Score:  0.209
Data Source:  BioPlex,STRINGDB
DENND4A
Tbio
Novelty:  0.22983311
p_int:  0.999447019
p_ni:  0.00055298
p_wrong:  1e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
TYW5
Tbio
Novelty:  0.1382439
p_int:  0.999304081
p_ni:  0.000695919
Score:  0.205
Data Source:  BioPlex,STRINGDB
PDLIM5
Tbio
Novelty:  0.0040646
p_int:  0.929207909
p_ni:  0.07079209
Score:  0.219
Data Source:  BioPlex,STRINGDB
FOXC1
Tbio
Family:  TF
Novelty:  0.00387011
p_int:  0.927713014
p_ni:  0.07227317
p_wrong:  0.000013816
Score:  0.219
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.753869326
p_ni:  0.246130674
Score:  0.216
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
Score:  0.825
Data Source:  STRINGDB
SARS
Tbio
Family:  Enzyme
Novelty:  0.00963508
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diverticular disease
1
1
0
1.1
42.3
1
1
0
1.3
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diverticular disease
0
1.1
42.3
0
1.3
33.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 6
VGNC:2042
743647
Macaque
methyltransferase like 6
694202
Mouse
MGI:1914261
67011
Rat
RGD:1359565
290564
Dog
methyltransferase like 6
477061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 6
Macaque
methyltransferase like 6
Mouse
Rat
Dog
methyltransferase like 6
Publication Statistics
PubMed Score 2.70
PubMed score by year
PubTator Score 1.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title