Tbio METTL23 Methyltransferase-like protein 23

Protein Summary

Description

Probable methyltransferase. The protein encoded by this gene functions as a transcription factor regulator in the transcriptional pathway for human cognition. It is a partner of the alpha subunit of the GA-binding protein transcription factor. Mutations in this gene cause mild autosomal recessive intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q86XA0
• H9ZYJ0
• K7EK32

Gene Name

• METTL23

Ensembl ID

• ENST00000341249
• ENSP00000341543
• ENSG00000181038
• ENST00000586752
• ENSP00000466203
• ENST00000588822
• ENSP00000465430
• ENST00000590964
• ENSP00000465890
• ENST00000615984
• ENSP00000482599

Symbol

• C17orf95
• MRT44
• C17orf95

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
transcription factor binding site profile	0.78
transcription factor perturbation	0.68
kinase perturbation	0.66
tissue sample	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 8   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0