METTL21A
Protein N-lysine methyltransferase METTL21A
Protein Summary
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
- ENST00000406927
- ENSP00000385481
- ENSG00000144401
- ENST00000411432
- ENSP00000415115
- ENST00000425132
- ENSP00000400730
- ENST00000426075
- ENSP00000403317
- ENST00000442521
- ENSP00000392062
- ENST00000448007
- ENSP00000407622
- ENST00000458426
- ENSP00000389684
- FAM119A
- HCA557B
- FAM119A
- HCA557b
- HSPA-KMT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
histone modification site profile | 0.84 | ||
transcription factor binding site profile | 0.83 | ||
transcription factor perturbation | 0.68 | ||
transcription factor | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.46 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.46 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0