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Tdark
METTL18
Histidine protein methyltransferase 1 homolog

Protein Summary
Description
Probable histidine methyltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303469
  • ENSP00000307077
  • ENSG00000171806
  • ENST00000310392
  • ENSP00000307975

Symbol
  • ASTP2
  • C1orf156
  • HPM1
  • AsTP2
  • C1orf156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
disease perturbation
0.79
transcription factor binding site profile
0.77
cell type or tissue
0.62
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.999998852
p_ni:  0.000001147
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
SSX2
Tbio
Novelty:  0.00227167
p_int:  0.999495399
p_ni:  0.00041346
p_wrong:  0.000091141
Score:  0.319
Data Source:  BioPlex,STRINGDB
VCPKMT
Tbio
Family:  Enzyme
Novelty:  0.37849297
Score:  0.886
Data Source:  STRINGDB
METTL21A
Tbio
Family:  Enzyme
Novelty:  0.31897774
Score:  0.885
Data Source:  STRINGDB
ETFBKMT
Tbio
Family:  Enzyme
Novelty:  0.33247149
Score:  0.842
Data Source:  STRINGDB
METTL21C
Tbio
Family:  Enzyme
Novelty:  0.14890496
Score:  0.798
Data Source:  STRINGDB
METTL22
Tdark
Family:  Enzyme
Novelty:  0.83516873
Score:  0.797
Data Source:  STRINGDB
KIN
Tbio
Novelty:  0.01425955
Score:  0.792
Data Source:  STRINGDB
EEF2KMT
Tdark
Family:  Enzyme
Novelty:  0.33892681
Score:  0.791
Data Source:  STRINGDB
RPL3
Tbio
Novelty:  0.00566964
Score:  0.778
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
e-selectin measurement
1
1
1
82.2
monocyte count
1
1
1
78.3
myeloid white cell count
2
2
2
77.6
1
1
1
72.2
monocyte percentage of leukocytes
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
e-selectin measurement
1
82.2
monocyte count
1
78.3
myeloid white cell count
2
77.6
1
72.2
monocyte percentage of leukocytes
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 18
VGNC:1317
469576
Macaque
methyltransferase like 18
701890
Mouse
MGI:1917212
69962
Rat
RGD:1306783
304928
Dog
methyltransferase like 18
VGNC:43173
100685478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 18
Macaque
methyltransferase like 18
Mouse
Rat
Dog
methyltransferase like 18
Publication Statistics
PubMed Score 3.95
PubMed score by year
PubTator Score 4.50
PubTator score by year
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Related Publications
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PMID
Year
Title