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Tdark
METTL15
Probable methyltransferase-like protein 15

Protein Summary
Description
Probable S-adenosyl-L-methionine-dependent methyltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303459
  • ENSP00000307251
  • ENSG00000169519
  • ENST00000406787
  • ENSP00000385507
  • ENST00000407364
  • ENSP00000384369
  • ENST00000437814
  • ENSP00000392806

Symbol
  • METT5D1
  • METT5D1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
cellular component
0.75
transcription factor
0.66
cell type or tissue
0.65
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.999997517
p_ni:  0.000002483
Data Source:  BioPlex
RBFA
Tbio
Novelty:  0.1061138
p_int:  0.999996433
p_ni:  0.000003566
Score:  0.554
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999821434
p_ni:  0.000178564
p_wrong:  2e-9
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.998504985
p_ni:  0.001490178
p_wrong:  0.000004838
Data Source:  BioPlex
LIPT1
Tdark
Family:  Enzyme
Novelty:  0.0546324
p_int:  0.995453435
p_ni:  0.004546557
p_wrong:  8e-9
Score:  0.373
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.995124628
p_ni:  0.004875013
p_wrong:  3.59e-7
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.99367359
p_ni:  0.006326407
p_wrong:  3e-9
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.992064045
p_ni:  0.007635054
p_wrong:  0.0003009
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.990072829
p_ni:  0.009926862
p_wrong:  3.08e-7
Data Source:  BioPlex
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.976894143
p_ni:  0.023105816
p_wrong:  4.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
57.1
sleep duration
1
1
1
21.5
triglyceride measurement
1
1
1
21.5
Beta blocking agent use measurement
1
1
1
21.5
1
1
0
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
57.1
sleep duration
1
21.5
triglyceride measurement
1
21.5
Beta blocking agent use measurement
1
21.5
0
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 15
VGNC:11921
451096
Mouse
MGI:1924144
76894
Dog
methyltransferase like 15
VGNC:52267
476897
Cow
methyltransferase like 15
533987
Pig
methyltransferase like 15
100517930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyltransferase like 15
Mouse
Dog
methyltransferase like 15
Cow
methyltransferase like 15
Pig
methyltransferase like 15
Publication Statistics
PubMed Score 2.77
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title