METTL1
tRNA (guanine-N(7)-)-methyltransferase
Protein Summary
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
- ENST00000257848
- ENSP00000257848
- ENSG00000037897
- ENST00000324871
- ENSP00000314441
- C12orf1
- TRM8
- TRMT8
- C12orf1
- YDL201w
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.77 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.99 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 158 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.99 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 158 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0