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Tclin
MET
Hepatocyte growth factor receptor

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, parti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318493
  • ENSP00000317272
  • ENSG00000105976
  • ENST00000397752
  • ENSP00000380860
  • ENST00000436117
  • ENSP00000410980

Symbol
  • HGFR
  • AUTS9
  • RCCP2
  • c-Met
  • DFNB97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
1
biological process
0.99
hub protein
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2667.81   (req: < 5)
Gene RIFs: 999   (req: <= 3)
Antibodies: 2650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2667.81   (req: >= 5)
Gene RIFs: 999   (req: > 3)
Antibodies: 2650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1625
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (357)
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999847554
p_ni:  0.000152445
Data Source:  BioPlex
PCBP1
Tbio
Novelty:  0.00906713
p_int:  0.998289355
p_ni:  0.000007336
p_wrong:  0.001703309
Score:  0.294
Data Source:  BioPlex,STRINGDB
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.996550764
p_ni:  0.003183915
p_wrong:  0.00026532
Score:  0.169
Data Source:  BioPlex,STRINGDB
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.966938894
p_ni:  0.023924235
p_wrong:  0.009136871
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.935927452
p_ni:  0.051782687
p_wrong:  0.012289861
Data Source:  BioPlex
HGF
Tchem
Family:  Enzyme
Novelty:  0.00035574
Score:  0.999
Data Source:  Reactome,STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.987
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.986
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.978
Data Source:  Reactome,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (400)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
90.9
mean platelet volume
1
1
1
78.4
platelet crit
2
2
2
75.7
triglyceride measurement
4
2
4
70.4
sex hormone-binding globulin measurement
4
2
4
69.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
90.9
mean platelet volume
1
78.4
platelet crit
2
75.7
triglyceride measurement
4
70.4
sex hormone-binding globulin measurement
4
69.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MET proto-oncogene, receptor tyrosine kinase
VGNC:4426
463671
Macaque
MET proto-oncogene, receptor tyrosine kinase
704562
Mouse
MGI:96969
17295
Rat
RGD:3082
24553
Dog
MET proto-oncogene, receptor tyrosine kinase
VGNC:43166
403438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MET proto-oncogene, receptor tyrosine kinase
Macaque
MET proto-oncogene, receptor tyrosine kinase
Mouse
Rat
Dog
MET proto-oncogene, receptor tyrosine kinase
Publication Statistics
PubMed Score 2667.81
PubMed score by year
PubTator Score 1670.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title