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Tbio
MEST
Mesoderm-specific transcript homolog protein

Protein Summary
Description
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223215
  • ENSP00000223215
  • ENSG00000106484
  • ENST00000341441
  • ENSP00000342749
  • ENST00000378576
  • ENSP00000367839
  • ENST00000393187
  • ENSP00000376884
  • ENST00000416162
  • ENSP00000408933
  • ENST00000427521
  • ENSP00000409505
  • ENST00000462132
  • ENSP00000495770

Symbol
  • PEG1
  • PEG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.84
gene perturbation
0.83
PubMedID
0.83
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.76   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.76   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
SNRPN
Tbio
Novelty:  0.002157
Score:  0.831
Data Source:  STRINGDB
PEG3
Tbio
Family:  TF
Novelty:  0.00367006
Score:  0.749
Data Source:  STRINGDB
PEG10
Tbio
Novelty:  0.00478545
Score:  0.718
Data Source:  STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.711
Data Source:  STRINGDB
COPG2
Tbio
Novelty:  0.06126837
Score:  0.687
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.685
Data Source:  STRINGDB
NNAT
Tbio
Novelty:  0.01079637
Score:  0.677
Data Source:  STRINGDB
DLK1
Tchem
Novelty:  0.00212394
Score:  0.661
Data Source:  STRINGDB
PLAGL1
Tbio
Family:  TF
Novelty:  0.00845226
Score:  0.659
Data Source:  STRINGDB
ZIM2
Tbio
Family:  TF
Novelty:  0.08135678
Score:  0.657
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
4
4
81.1
BMI-adjusted hip circumference
1
3
3
70
waist circumference
1
2
2
59.7
BMI-adjusted waist circumference
1
2
2
52.7
waist-hip ratio
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
4
81.1
BMI-adjusted hip circumference
3
70
waist circumference
2
59.7
BMI-adjusted waist circumference
2
52.7
waist-hip ratio
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mesoderm specific transcript
463729
Mouse
MGI:96968
17294
Rat
RGD:1594589
58827
Dog
mesoderm specific transcript
VGNC:43165
607717
Horse
mesoderm specific transcript
VGNC:20110
100057213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mesoderm specific transcript
Mouse
Rat
Dog
mesoderm specific transcript
Horse
mesoderm specific transcript
Publication Statistics
PubMed Score 449.76
PubMed score by year
PubTator Score 164.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title