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Tbio
MEST
Mesoderm-specific transcript homolog protein

Protein Summary
Description
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223215
  • ENSP00000223215
  • ENSG00000106484
  • ENST00000341441
  • ENSP00000342749
  • ENST00000378576
  • ENSP00000367839
  • ENST00000393187
  • ENSP00000376884
  • ENST00000416162
  • ENSP00000408933
  • ENST00000427521
  • ENSP00000409505
  • ENST00000462132
  • ENSP00000495770

Symbol
  • PEG1
  • PEG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.84
gene perturbation
0.83
PubMedID
0.83
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 669.26   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 669.26   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0