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Tbio
MEMO1
Protein MEMO1

Protein Summary
Description
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295065
  • ENSP00000295065
  • ENSG00000162959
  • ENST00000379383
  • ENSP00000368691
  • ENST00000404530
  • ENSP00000385557
  • ENST00000426310
  • ENSP00000400795

Symbol
  • C2orf4
  • MEMO
  • NS5ATP7
  • MEMO
  • C2orf4
  • CGI-27
  • NS5ATP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
interacting protein
0.76
transcription factor binding site profile
0.75
histone modification site profile
0.67
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
HMBOX1
Tbio
Family:  TF
Novelty:  0.02455652
p_int:  0.999999981
p_ni:  1.5e-8
p_wrong:  4e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999666514
p_ni:  0.000333479
p_wrong:  7e-9
Data Source:  BioPlex
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.999610776
p_ni:  0.000389132
p_wrong:  9.3e-8
Score:  0.6
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.989470644
p_ni:  0.010529356
Score:  0.196
Data Source:  BioPlex,STRINGDB
UPF1
Tbio
Novelty:  0.00311006
p_int:  0.973421749
p_ni:  0.026578251
Score:  0.184
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.935677257
p_ni:  0.00148215
p_wrong:  0.062840592
Score:  0.169
Data Source:  BioPlex,STRINGDB
CD93
Tbio
Novelty:  0.01324003
p_int:  0.924766217
p_ni:  0.075233783
Score:  0.188
Data Source:  BioPlex,STRINGDB
CGGBP1
Tbio
Novelty:  0.10880271
p_int:  0.872145225
p_ni:  0.127854775
Data Source:  BioPlex
TARBP2
Tchem
Novelty:  0.01485994
p_int:  0.7656602
p_ni:  0.234336936
p_wrong:  0.000002864
Score:  0.173
Data Source:  BioPlex,STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.968
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ERBB2 Regulates Cell Motility (R-HSA-6785631)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ERBB2 Regulates Cell Motility
Reactome
Signal Transduction
Reactome
Signaling by ERBB2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
ERBB2 Regulates Cell Motility
Signal Transduction
Signaling by ERBB2
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
88.2
1
1
1
86.1
interleukin 18 measurement
1
1
1
50.4
interleukin 1 receptor antagonist measurement
1
1
1
49.9
interleukin-1 beta measurement
1
1
1
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
88.2
1
86.1
interleukin 18 measurement
1
50.4
interleukin 1 receptor antagonist measurement
1
49.9
interleukin-1 beta measurement
1
49.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mediator of cell motility 1
706051
Mouse
MGI:1924140
76890
Rat
RGD:1309929
298787
Dog
mediator of cell motility 1 [Source:HGNC Symbol;Acc:HGNC:14014]
Horse
mediator of cell motility 1
VGNC:20103
100147678
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mediator of cell motility 1
Mouse
Rat
Dog
mediator of cell motility 1 [Source:HGNC Symbol;Acc:HGNC:14014]
Horse
mediator of cell motility 1
Publication Statistics
PubMed Score 31.41
PubMed score by year
PubTator Score 16.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title