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Tbio
MEIS2
Homeobox protein Meis2

Protein Summary
Description
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314177
  • ENSP00000326296
  • ENSG00000134138
  • ENST00000338564
  • ENSP00000341400
  • ENST00000340545
  • ENSP00000339549
  • ENST00000397620
  • ENSP00000380745
  • ENST00000397624
  • ENSP00000380749
  • ENST00000424352
  • ENSP00000404185
  • ENST00000557796
  • ENSP00000452693
  • ENST00000559085
  • ENSP00000453390
  • ENST00000559561
  • ENSP00000453497
  • ENST00000561208
  • ENSP00000453793

Symbol
  • MRG1
  • MRG1
  • CPCMR
  • HsT18361
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
PubMedID
0.95
kinase perturbation
0.91
transcription factor
0.91
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.39   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.39   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0