Tbio MEF2D Myocyte-specific enhancer factor 2D

Protein Summary

Description

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q14814
• D3DVC0
• Q14815
• Q5T9U5
• Q5T9U6

Gene Name

• MEF2D

Ensembl ID

• ENST00000348159
• ENSP00000271555
• ENSG00000116604
• ENST00000360595
• ENSP00000353803
• ENST00000464356
• ENSP00000476788

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
transcription factor binding site profile	0.97
transcription factor perturbation	0.88
hub protein	0.85
PubMedID	0.84

Protein Classes

PANTHER Classes

Protein / ... / Mads Box Transcription Factor / Myocyte-specific Enhancer Factor 2d

DTO Classes

Protein / Transcription Factor / Mads Box Transcription Factor / Myocyte-specific Enhancer Factor 2d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.34   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 408   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.34   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (121)

Explore Interacting Targets

1 – 10 of 121

• See Interactions on String-DB

MEF2B

Tbio

Family:  TF

Novelty:  0.03094093

p_int:  0.999999974

p_ni:  9e-9

p_wrong:  1.7e-8

Score:  0.172

Data Source:  BioPlex,STRINGDB

WRAP53

Tbio

Family:  Enzyme

Novelty:  0.0204638

p_int:  0.99999902

p_ni:  9.73e-7

p_wrong:  8e-9

Data Source:  BioPlex

MAPK14

Tchem

Family:  Kinase

Novelty:  0.00045138

p_int:  0.994952324

p_ni:  0.000004268

p_wrong:  0.005043408

Score:  0.959

Data Source:  BioPlex,STRINGDB

CABIN1

Tbio

Novelty:  0.02528794

Score:  0.99

Data Source:  STRINGDB

EP300

Tchem

Family:  Epigenetic

Novelty:  0.00055009

Score:  0.988

Data Source:  STRINGDB

CREBBP

Tchem

Family:  Epigenetic

Novelty:  0.00111166

Score:  0.981

Data Source:  STRINGDB

MYOG

Tbio

Family:  TF

Novelty:  0.00074867

Score:  0.98

Data Source:  STRINGDB

HDAC5

Tclin

Family:  Epigenetic

Novelty:  0.00484422

Score:  0.979

Data Source:  STRINGDB

MYOD1

Tbio

Family:  TF

Novelty:  0.00053412

Score:  0.978

Data Source:  STRINGDB

MAPK7

Tchem

Family:  Kinase

Novelty:  0.00257226

Score:  0.977

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (23)

Reactome (6)

KEGG (3)

PathwayCommons (4)

WikiPathways (10)

Circadian Clock (R-HSA-400253)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Circadian Clock	69 targets	R-HSA-400253
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Mitochondrial biogenesis	89 targets	R-HSA-1592230
Reactome	Myogenesis	29 targets	R-HSA-525793
Reactome	Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Name	Explore in Pharos	Explore in Source
Circadian Clock	69 targets	R-HSA-400253
Developmental Biology	1055 targets	R-HSA-1266738
Mitochondrial biogenesis	89 targets	R-HSA-1592230
Myogenesis	29 targets	R-HSA-525793
Organelle biogenesis and maintenance	276 targets	R-HSA-1852241

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (10)

Components (5)

Processes (10)

Find Similar Targets

Items per page:

10

1 – 10 of 10

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
activating transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
histone deacetylase binding	Inferred from Physical Interaction (IPI)	UniProtKB
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity	Non-traceable Author Statement (NAS)	ProtInc
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein homodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	2	2	2		91.8
migraine disorder	EFO_0003821	4	4	0	1.1	90.6
platelet count	EFO_0004309	2	2	2		81.2
TPE interval measurement	EFO_0004644	1	1	3		79.6
BMI-adjusted waist circumference	EFO_0007789	2	5	5		70.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	2		91.8
migraine disorder	EFO_0003821	0	1.1	90.6
platelet count	EFO_0004309	2		81.2
TPE interval measurement	EFO_0004644	3		79.6
BMI-adjusted waist circumference	EFO_0007789	5		70.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Activator
Alternative splicing
Apoptosis
Complete proteome
Developmental protein
Differentiation
DNA-binding
Isopeptide bond
Neurogenesis

GWAS Trait Find Similar Targets

No Header	No Header
Antimigraine preparation use measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body height
body mass index
creatine kinase measurement
electrocardiography
Headache
leukocyte count
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
muscle phenotype
nervous system phenotype
respiratory system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myocyte enhancer factor 2D	VGNC:1316	457396
Macaque	myocyte enhancer factor 2D		718449
Mouse	myocyte enhancer factor 2D	MGI:99533	17261
Rat	myocyte enhancer factor 2D	RGD:621489	81518
Dog	myocyte enhancer factor 2D	VGNC:43145	490413

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myocyte enhancer factor 2D
Macaque	myocyte enhancer factor 2D
Mouse	myocyte enhancer factor 2D
Rat	myocyte enhancer factor 2D
Dog	myocyte enhancer factor 2D

Publication Statistics

PubMed Score 154.34

PubMed score by year

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PubTator Score 53.29

PubTator score by year

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Related Publications

Text Mined References (72)

GeneRif Annotations (35)

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PMID	Year	Title