Tbio MEF2A Myocyte-specific enhancer factor 2A

Protein Summary

Description

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q02078
• B4DFQ7
• F6XG23
• O43814
• Q14223
• Q14224
• Q59GX4
• Q7Z6C9
• Q96D14

Gene Name

• MEF2A

Ensembl ID

• ENST00000338042
• ENSP00000337202
• ENSG00000068305
• ENST00000354410
• ENSP00000346389
• ENST00000449277
• ENSP00000399460
• ENST00000557785
• ENSP00000453441
• ENST00000557942
• ENSP00000453095
• ENST00000558812
• ENSP00000454120

Symbol

• MEF2
• mef2
• ADCAD1
• RSRFC4
• RSRFC9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
transcription factor perturbation	1
biological process	0.99
hub protein	0.95
transcription factor	0.9

Protein Classes

PANTHER Classes

Protein / ... / Mads Box Transcription Factor / Myocyte-specific Enhancer Factor 2a

DTO Classes

Protein / Transcription Factor / Mads Box Transcription Factor / Myocyte-specific Enhancer Factor 2a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.82   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 970   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.82   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 970   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0