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Tbio
MED18
Mediator of RNA polymerase II transcription subunit 18

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373842
  • ENSP00000362948
  • ENSG00000130772
  • ENST00000398997
  • ENSP00000381963
  • ENST00000645794
  • ENSP00000494184
  • ENSG00000284944
  • ENST00000647352
  • ENSP00000494048

Symbol
  • SRB5
  • p28b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.82
small molecule perturbation
0.7
tissue sample
0.64
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
MED8
Tbio
Family:  Enzyme
Novelty:  0.06648307
p_int:  0.99999996
p_ni:  3.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED26
Tbio
Family:  Enzyme
Novelty:  0.05663538
p_int:  0.999999958
p_ni:  3.8e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED27
Tbio
Family:  Enzyme
Novelty:  0.02511389
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999999926
p_ni:  7.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
p_int:  0.99999981
p_ni:  1.9e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
69.3
aspartate aminotransferase measurement
1
1
0
7.3
58.4
uric acid measurement
1
1
1
26.6
eosinophil count
2
1
2
17.7
eosinophil percentage of leukocytes
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
69.3
aspartate aminotransferase measurement
0
7.3
58.4
uric acid measurement
1
26.6
eosinophil count
2
17.7
eosinophil percentage of leukocytes
1
12.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 18
VGNC:1315
456683
Macaque
mediator complex subunit 18
716930
Mouse
MGI:1914469
67219
Dog
mediator complex subunit 18
VGNC:43127
487334
Horse
mediator complex subunit 18
VGNC:20076
100056505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 18
Macaque
mediator complex subunit 18
Mouse
Dog
mediator complex subunit 18
Horse
mediator complex subunit 18
Publication Statistics
PubMed Score 24.55
PubMed score by year
PubTator Score 4.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title