Tbio MECOM MDS1 and EVI1 complex locus protein

Protein Summary

Description

Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q03112
• A1L4F3
• A8KA00
• B7Z8W7
• B7ZLQ3
• B7ZLQ4
• C9JAK0
• D3DNP7
• E7EQ57
• Q13465
• Q13466
• Q16122
• Q5HYI1
• Q6FH90
• Q6MZS6
• Q8NEI5
• Q99917

Gene Name

• MECOM

Ensembl ID

• ENST00000264674
• ENSP00000264674
• ENSG00000085276
• ENST00000464456
• ENSP00000419770
• ENST00000468789
• ENSP00000419995
• ENST00000494292
• ENSP00000417899
• ENST00000628990
• ENSP00000486104

Symbol

• EVI1
• MDS1
• EVI1
• MDS1
• KMT8E
• PRDM3
• RUSAT2
• MDS1-EVI1
• AML1-EVI-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.79   (req: < 5)

Gene RIFs: 165   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.79   (req: >= 5)

Gene RIFs: 165   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0