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Tbio
ME3
NADP-dependent malic enzyme, mitochondrial

Protein Summary
Description
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393324
  • ENSP00000376998
  • ENSG00000151376
  • ENST00000526504
  • ENSP00000433636
  • ENST00000543262
  • ENSP00000440246

Symbol
  • NADP-ME
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.84
protein domain
0.73
cellular component
0.66
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
MDH2
Tchem
Family:  Enzyme
Novelty:  0.00217694
Score:  0.978
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.972
Data Source:  STRINGDB
MDH1
Tchem
Family:  Enzyme
Novelty:  0.00203876
Score:  0.971
Data Source:  STRINGDB
PKLR
Tclin
Family:  Kinase
Novelty:  0.00268398
Score:  0.965
Data Source:  STRINGDB
FH
Tbio
Family:  Enzyme
Novelty:  0.00455957
Score:  0.957
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.956
Data Source:  STRINGDB
PDHA1
Tbio
Family:  Enzyme
Novelty:  0.00392231
Score:  0.931
Data Source:  STRINGDB
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
Score:  0.92
Data Source:  STRINGDB
PDHA2
Tbio
Family:  Enzyme
Novelty:  0.06188763
Score:  0.919
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
5
90.7
red blood cell distribution width
2
1
2
54.5
lymphocyte count
1
1
1
37.7
red blood cell density measurement
1
1
1
34.6
mean reticulocyte volume
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
90.7
red blood cell distribution width
2
54.5
lymphocyte count
1
37.7
red blood cell density measurement
1
34.6
mean reticulocyte volume
1
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
malic enzyme 3
704422
Mouse
MGI:1916679
109264
Rat
RGD:1311070
361602
Dog
malic enzyme 3
VGNC:43111
485151
Horse
malic enzyme 3
VGNC:20063
100061008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
malic enzyme 3
Mouse
Rat
Dog
malic enzyme 3
Horse
malic enzyme 3
Publication Statistics
PubMed Score 370.75
PubMed score by year
PubTator Score 50.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title