Tchem MDM4 Protein Mdm4

Protein Summary

Description

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• O15151
• Q2M2Y2
• Q32SL2
• Q6GS18
• Q8IV83

Gene Name

• MDM4

Ensembl ID

• ENST00000367182
• ENSP00000356150
• ENSG00000198625
• ENST00000367183
• ENSP00000356151
• ENST00000454264
• ENSP00000396840

Symbol

• MDMX
• HDMX
• MDMX
• MRP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.97
microRNA	0.91
transcription factor binding site profile	0.91
kinase	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Mdm4

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Mdm4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.34   (req: < 5)

Gene RIFs: 213   (req: <= 3)

Antibodies: 631   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.34   (req: >= 5)

Gene RIFs: 213   (req: > 3)

Antibodies: 631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 90

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0