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Tchem
MDM2
E3 ubiquitin-protein ligase Mdm2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258149
  • ENSP00000258149
  • ENSG00000135679
  • ENST00000299252
  • ENSP00000299252
  • ENST00000360430
  • ENSP00000353611
  • ENST00000393413
  • ENSP00000377065
  • ENST00000539479
  • ENSP00000444430

Symbol
  • HDMX
  • hdm2
  • ACTFS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
co-expressed gene
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3371.47   (req: < 5)
Gene RIFs: 1198   (req: <= 3)
Antibodies: 1567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3371.47   (req: >= 5)
Gene RIFs: 1198   (req: > 3)
Antibodies: 1567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1818
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (628)
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.998846003
p_ni:  0.001151638
p_wrong:  0.00000236
Score:  0.997
Data Source:  BioPlex,STRINGDB
MDM4
Tchem
Novelty:  0.00321558
p_int:  0.997672205
p_ni:  0.002327777
p_wrong:  1.8e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
p_int:  0.995110144
p_ni:  0.004889856
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.988675145
p_ni:  0.011324855
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.986989065
p_ni:  0.013010934
Data Source:  BioPlex
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.983157919
p_ni:  0.016842078
p_wrong:  3e-9
Data Source:  BioPlex
H2AFB1
Tbio
Novelty:  0.08770329
p_int:  0.965155024
p_ni:  0.034844976
Data Source:  BioPlex
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.959685411
p_ni:  0.040314588
p_wrong:  1e-9
Data Source:  BioPlex
RPS7
Tbio
Novelty:  0.00745987
p_int:  0.959489475
p_ni:  0.040390476
p_wrong:  0.000120049
Score:  0.599
Data Source:  BioPlex,STRINGDB
PPARD
Tchem
Family:  NR
Novelty:  0.00271873
p_int:  0.953782302
p_ni:  0.046217658
p_wrong:  4e-8
Score:  0.698
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
1 – 2 of 2
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  18
more:  14 more common pathways
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  18
more:  14 more common pathways
Pathways (113)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (88)
Find Similar Targets
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
44.2
mean reticulocyte volume
1
1
1
29
red blood cell density measurement
1
1
1
21.4
mean corpuscular volume
1
1
1
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
44.2
mean reticulocyte volume
1
29
red blood cell density measurement
1
21.4
mean corpuscular volume
1
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MDM2 proto-oncogene
718284
Mouse
MGI:96952
17246
Rat
RGD:1305332
314856
Dog
MDM2 proto-oncogene
VGNC:43106
403693
Horse
MDM2 proto-oncogene
VGNC:20059
100052084
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MDM2 proto-oncogene
Mouse
Rat
Dog
MDM2 proto-oncogene
Horse
MDM2 proto-oncogene
Publication Statistics
PubMed Score 3371.47
PubMed score by year
PubTator Score 3055.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title