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Tchem
MDM2
E3 ubiquitin-protein ligase Mdm2

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258149
  • ENSP00000258149
  • ENSG00000135679
  • ENST00000299252
  • ENSP00000299252
  • ENST00000360430
  • ENSP00000353611
  • ENST00000393413
  • ENSP00000377065
  • ENST00000539479
  • ENSP00000444430

Symbol
  • HDMX
  • hdm2
  • ACTFS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
co-expressed gene
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3735.32   (req: < 5)
Gene RIFs: 1198   (req: <= 3)
Antibodies: 1567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3735.32   (req: >= 5)
Gene RIFs: 1198   (req: > 3)
Antibodies: 1567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1834
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3