MDH2
Malate dehydrogenase, mitochondrial
Protein Summary
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
- ENST00000315758
- ENSP00000327070
- ENSG00000146701
- ENST00000432020
- ENSP00000408649
- MDH
- MOR1
- M-MDH
- EIEE51
- MGC:3559
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 0.99 | ||
protein domain | 0.92 | ||
cellular component | 0.89 | ||
histone modification site profile | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 603.95 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 343 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 603.95 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 343 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0