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Tbio
MDC1
Mediator of DNA damage checkpoint protein 1

Protein Summary
Description
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX nea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376406
  • ENSP00000365588
  • ENSG00000137337
  • ENST00000383566
  • ENSP00000373060
  • ENSG00000206481
  • ENST00000420019
  • ENSP00000396484
  • ENSG00000224587
  • ENST00000420320
  • ENSP00000416511
  • ENSG00000225589
  • ENST00000427406
  • ENSP00000387429
  • ENSG00000234012
  • ENST00000435664
  • ENSP00000404318
  • ENSG00000231135
  • ENST00000440369
  • ENSP00000415212
  • ENSG00000228575
  • ENST00000449153
  • ENSP00000409167
  • ENSG00000237095

Symbol
  • KIAA0170
  • NFBD1
  • NFBD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
hub protein
0.92
kinase
0.89
drug perturbation
0.87
transcription factor
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.19   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.19   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0