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Tbio
MCUR1
Mitochondrial calcium uniporter regulator 1

Protein Summary
Description
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379170
  • ENSP00000368468
  • ENSG00000050393
  • ENST00000488770
  • ENSP00000476162

Symbol
  • C6orf79
  • CCDC90A
  • FMP32
  • C6orf79
  • CCDC90A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.7
transcription factor perturbation
0.68
cellular component
0.63
tissue sample
0.61
histone modification site profile
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.09   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.09   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CCDC90B
Tdark
Novelty:  0.64520265
p_int:  1
Score:  0.552
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.99964027
p_ni:  0.0000016
p_wrong:  0.00035813
Score:  0.216
Data Source:  BioPlex,STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
p_int:  0.983910359
p_ni:  0.016089641
Score:  0.395
Data Source:  BioPlex,STRINGDB
MCU
Tbio
Family:  IC
Novelty:  0.00114914
Score:  0.968
Data Source:  STRINGDB
MICU2
Tbio
Novelty:  0.04146208
Score:  0.93
Data Source:  STRINGDB
MCUB
Tbio
Novelty:  0.0486243
Score:  0.918
Data Source:  STRINGDB
MICU1
Tbio
Novelty:  0.00984731
Score:  0.909
Data Source:  STRINGDB
SMDT1
Tbio
Novelty:  0.02448475
Score:  0.873
Data Source:  STRINGDB
LETM1
Tbio
Novelty:  0.01542461
Score:  0.787
Data Source:  STRINGDB
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
12
2
1
0
1.1
6.8
intelligence
1
1
0
5.5
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
12
0
1.1
6.8
intelligence
0
5.5
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter regulator 1
VGNC:3459
462445
Macaque
mitochondrial calcium uniporter regulator 1
701463
Mouse
MGI:1923387
76137
Rat
RGD:1307673
291034
Horse
mitochondrial calcium uniporter regulator 1
VGNC:20051
100065066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter regulator 1
Macaque
mitochondrial calcium uniporter regulator 1
Mouse
Rat
Horse
mitochondrial calcium uniporter regulator 1
Publication Statistics
PubMed Score 14.09
PubMed score by year
PubTator Score 5.78
PubTator score by year
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Related Publications
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PMID
Year
Title