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Tbio
MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

Protein Summary
Description
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394650
  • ENSP00000378145
  • ENSG00000005059

Symbol
  • CCDC109B
  • CCDC109B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.999999732
p_ni:  2.68e-7
Data Source:  BioPlex
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.999999716
p_ni:  2.82e-7
p_wrong:  1e-9
Score:  0.674
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.999471081
p_ni:  0.000528919
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999427711
p_ni:  0.0002405
p_wrong:  0.000331789
Score:  0.432
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.998070002
p_ni:  0.001916485
p_wrong:  0.000013514
Data Source:  BioPlex
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.996035418
p_ni:  0.003956693
p_wrong:  0.000007889
Score:  0.158
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.961583655
p_ni:  0.003567731
p_wrong:  0.034848615
Score:  0.205
Data Source:  BioPlex,STRINGDB
MICU2
Tbio
Novelty:  0.04146208
Score:  0.989
Data Source:  STRINGDB
MICU1
Tbio
Novelty:  0.00984731
Score:  0.984
Data Source:  STRINGDB
MICU3
Tbio
Novelty:  0.09752188
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
84.5
apolipoprotein A 1 measurement
2
2
3
84.5
3
3
0
1.2
81.4
atrophic macular degeneration
1
2
0
2.4
71.5
2
2
0
1.3
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
84.5
apolipoprotein A 1 measurement
3
84.5
0
1.2
81.4
atrophic macular degeneration
0
2.4
71.5
0
1.3
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter dominant negative beta subunit
VGNC:6474
461432
Mouse
MGI:1914065
66815
Rat
RGD:1305326
295462
Dog
mitochondrial calcium uniporter dominant negative beta subunit
VGNC:43097
478513
Horse
mitochondrial calcium uniporter dominant negative beta subunit
VGNC:20050
100072864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter dominant negative beta subunit
Mouse
Rat
Dog
mitochondrial calcium uniporter dominant negative beta subunit
Horse
mitochondrial calcium uniporter dominant negative beta subunit
Publication Statistics
PubMed Score 15.22
PubMed score by year
PubTator Score 4.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title