You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MCTS1
Malignant T-cell-amplified sequence 1

Protein Summary
Description
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371315
  • ENSP00000360365
  • ENSG00000232119
  • ENST00000371317
  • ENSP00000360367

Symbol
  • MCT1
  • MCT1
  • MCT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
transcription factor perturbation
0.74
tissue sample
0.66
histone modification site profile
0.64
transcription factor
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
DENR
Tbio
Novelty:  0.00653432
p_int:  0.999999991
p_ni:  9e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
RLN2
Tbio
Novelty:  0.00743118
p_int:  0.99828589
p_ni:  0.001714103
p_wrong:  7e-9
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.992800272
p_ni:  0.007199636
p_wrong:  9.2e-8
Data Source:  BioPlex
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.99051978
p_ni:  0.009480215
p_wrong:  5e-9
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.987924319
p_ni:  0.012075681
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.985659225
p_ni:  0.014340775
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.984896186
p_ni:  0.015103789
p_wrong:  2.5e-8
Data Source:  BioPlex
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.969977901
p_ni:  0.029459348
p_wrong:  0.000562751
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.945441801
p_ni:  0.054556589
p_wrong:  0.00000161
Data Source:  BioPlex
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.930089677
p_ni:  0.06990573
p_wrong:  0.000004593
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MCTS1, re-initiation and release factor
VGNC:1360
465836
Macaque
MCTS1, re-initiation and release factor
696543
Mouse
MGI:1916245
68995
Rat
RGD:1566390
302500
Dog
malignant T-cell-amplified sequence 1-like
487150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MCTS1, re-initiation and release factor
Macaque
MCTS1, re-initiation and release factor
Mouse
Rat
Dog
malignant T-cell-amplified sequence 1-like
Publication Statistics
PubMed Score 20.13
PubMed score by year
PubTator Score 7.59
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title