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Tbio
MCRS1
Microspherule protein 1

Protein Summary
Description
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343810
  • ENSP00000345358
  • ENSG00000187778
  • ENST00000357123
  • ENSP00000349640
  • ENST00000546244
  • ENSP00000444982
  • ENST00000550165
  • ENSP00000448056

Symbol
  • INO80Q
  • MSP58
  • P78
  • MCRS2
  • MSP58
  • INO80Q
  • ICP22BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.91
cellular component
0.75
transcription factor binding site profile
0.74
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
p_int:  0.999952274
p_ni:  0.000047726
Score:  0.989
Data Source:  BioPlex,STRINGDB
INO80C
Tdark
Novelty:  0.04242834
p_int:  0.9999502
p_ni:  0.0000498
Score:  0.947
Data Source:  BioPlex,STRINGDB
KANSL1
Tbio
Novelty:  0.03032662
p_int:  0.999943333
p_ni:  0.000056667
Score:  0.981
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999926939
p_ni:  0.000073061
Score:  0.939
Data Source:  BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.9998741
p_ni:  0.0001259
Data Source:  BioPlex
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999721635
p_ni:  0.000278365
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999668049
p_ni:  0.00033195
Data Source:  BioPlex
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.998960748
p_ni:  0.001039252
Data Source:  BioPlex
INO80
Tbio
Family:  Enzyme
Novelty:  0.09412936
p_int:  0.998358954
p_ni:  0.001631571
p_wrong:  0.000009475
Score:  0.937
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.998040602
p_ni:  0.001959398
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
71.8
self reported educational attainment
2
2
2
53.1
intelligence
2
2
2
40.5
alcohol consumption measurement
1
1
1
33.1
mathematical ability
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
71.8
self reported educational attainment
2
53.1
intelligence
2
40.5
alcohol consumption measurement
1
33.1
mathematical ability
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microspherule protein 1
VGNC:5468
451881
Macaque
microspherule protein 1
710919
Mouse
MGI:1858420
51812
Rat
RGD:1311607
300222
Dog
microspherule protein 1
VGNC:43093
477616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microspherule protein 1
Macaque
microspherule protein 1
Mouse
Rat
Dog
microspherule protein 1
Publication Statistics
PubMed Score 39.25
PubMed score by year
PubTator Score 46.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title